High-energy defibrillation impairs myocyte contractility and intracellular calcium dynamics

• Published in: Critical care medicine Vol. 36; no. 11 Suppl; p. S422
• Main Authors: Ristagno, Giuseppe, Wang, Tong, Tang, Wanchun, Sun, Shijie, Castillo, Carlos, Weil, Max Harry
• Format: Journal Article
• Language: English
• Published: United States 01.11.2008
• Subjects: Animals; Calcium - metabolism; Electric Countershock; Fura-2; In Vitro Techniques; Intracellular Fluid - metabolism; Male; Myocardial Contraction; Myocytes, Cardiac - physiology; Rats; Rats, Sprague-Dawley

We examined the effects of energy delivered with electrical defibrillation on myocyte contractility and intracellular Ca2+ dynamics. We hypothesized that increasing the defibrillation energy would produce correspondent reduction in myocyte contractility and intracellular Ca2+ dynamics. Randomized pr...