Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair

Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (T ) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of T in facilitating skin rep...

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Bibliographic Details
Published inScience immunology Vol. 5; no. 47
Main Authors Boothby, Ian C, Cohen, Jarish N, Rosenblum, Michael D
Format Journal Article
LanguageEnglish
Published United States 01.05.2020
Subjects
Animals
Humans
Immune Tolerance - immunology
Skin - immunology
Skin - injuries
T-Lymphocytes, Regulatory - immunology
Wound Healing - immunology
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Summary:Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (T ) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of T in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by "classical" suppressive mechanisms of T and by "nonclassical" reparative T functions.
ISSN:2470-9468
DOI:10.1126/sciimmunol.aaz9631