VEGF-B electrotransfer mediated gene therapy induces cardiomyogenesis in a rat model of cardiac ischemia

• Published in: Bioelectrochemistry (Amsterdam, Netherlands) Vol. 124; pp. 105 - 111
• Main Authors: Bulysheva, Anna A., Burcus, Nina, Lundberg, Cathryn G., Francis, Michael P., Heller, Richard
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2018; Elsevier BV
• Subjects: Adults; Arteriosclerosis; Atherosclerosis; Calcium-binding protein; Cardiac muscle; Cardiomyocytes; Cardiomyogenesis; Deoxyribonucleic acid; DNA; Fetuses; Gene electrotransfer; Gene therapy; Gene transfer; Heart; Heart attacks; Immunoreactivity; In vivo methods and tests; Ischemia; Localization; Muscles; Myocardial infarct; Myocardial infarction; Myogenesis; Public health; Regeneration; Rodents; Troponin; Vascular endothelial growth factor; Vascular endothelial growth factor B; Cardiomyogenesis; Myocardial infarct; Gene therapy; Gene electrotransfer; Vascular endothelial growth factor B

Atherosclerosis induced myocardial infarction (MI) continues to be a major public health concern. Regenerative therapies that restore cardiac muscle cells are largely absent. The rate of cardiomyogenesis in adults is insufficient to compensate for MI damage. In this study, we explored the capacity o...