Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter

• Published in: Thyroid (New York, N.Y.) Vol. 14; no. 12; p. 1012
• Main Authors: Tonacchera, Massimo, Pinchera, Aldo, Dimida, Antonio, Ferrarini, Eleonora, Agretti, Patrizia, Vitti, Paolo, Santini, Ferruccio, Crump, Kenny, Gibbs, John
• Format: Journal Article
• Language: English
• Published: United States 01.12.2004
• Subjects: Algorithms; Animals; Autoantibodies - immunology; CHO Cells; Cricetinae; Humans; Iodides - metabolism; Iodides - pharmacology; Iodine Radioisotopes; Models, Biological; Nitrates - pharmacology; Perchlorates - pharmacology; Symporters - metabolism; Thiocyanates - pharmacology; Transfection

The presence of perchlorate (ClO(4) (-)) in some U.S. drinking water supplies has raised concern about potential adverse thyroidal health effects, because ClO(4) (-) is known to competitively inhibit iodide uptake at the sodium iodide symporter (NIS). Humans are nutritionally and environmentally exp...