ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis

Vascular dementia is the second common cause of dementia, only second to Alzheimer’s disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chines...

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Published in	Journal of Neural Transmission Vol. 119; no. 3; pp. 387 - 394
Main Authors	Liu, Xu, Li, Lei, Liu, Fang, Deng, Shuming, Zhu, Ruixia, Li, Qu, He, Zhiyi
Format	Journal Article
Language	English
Published	Vienna Springer Vienna 01.03.2012 Springer Nature B.V
Subjects	Alleles Alzheimer's disease Apolipoprotein E Apolipoprotein E4 Apolipoproteins E - genetics Asian Continental Ancestry Group - genetics China Data processing Dementia disorders Dementia, Vascular - genetics Dementias - Original Article Gene Frequency Gene polymorphism Genetic Predisposition to Disease Humans Medicine Medicine & Public Health Neurodegenerative diseases Neurology Neurosciences Polymorphism, Genetic Population genetics Psychiatry Reviews Risk factors Systematic review vascular dementia China ApoE Vascular dementia Gene polymorphism Meta-analysis
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Abstract	Vascular dementia is the second common cause of dementia, only second to Alzheimer’s disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. Therefore, we performed this meta-analysis in order to evaluate the relationship between ApoE gene polymorphism and susceptibility to vascular dementia in Chinese population by pooling data from all relevant case–control studies published domestically and abroad from January 1990 to May 2011. 18 case–control studies were selected. Meta-analysis results showed that the pooled OR value of vascular dementia subjects in Chinese population with ε4 allele carriers was 2.07 [95% CI (1.69, 2.53)], and the pooled OR value of vascular dementia subjects with E4/E4 genotype was 3.34 [95% CI (1.89, 5.88)]. These results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population. The subject with at least one ε4 allele or E4/E4 genotype has higher risk suffering from vascular dementia than others.
AbstractList	Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. Therefore, we performed this meta-analysis in order to evaluate the relationship between ApoE gene polymorphism and susceptibility to vascular dementia in Chinese population by pooling data from all relevant case-control studies published domestically and abroad from January 1990 to May 2011. 18 case-control studies were selected. Meta-analysis results showed that the pooled OR value of vascular dementia subjects in Chinese population with epsilon 4 allele carriers was 2.07 [95% CI (1.69, 2.53)], and the pooled OR value of vascular dementia subjects with E4/E4 genotype was 3.34 [95% CI (1.89, 5.88)]. These results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population. The subject with at least one epsilon 4 allele or E4/E4 genotype has higher risk suffering from vascular dementia than others. Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. Therefore, we performed this meta-analysis in order to evaluate the relationship between ApoE gene polymorphism and susceptibility to vascular dementia in Chinese population by pooling data from all relevant case-control studies published domestically and abroad from January 1990 to May 2011. 18 case-control studies were selected. Meta-analysis results showed that the pooled OR value of vascular dementia subjects in Chinese population with ε4 allele carriers was 2.07 [95% CI (1.69, 2.53)], and the pooled OR value of vascular dementia subjects with E4/E4 genotype was 3.34 [95% CI (1.89, 5.88)]. These results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population. The subject with at least one ε4 allele or E4/E4 genotype has higher risk suffering from vascular dementia than others. Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. Therefore, we performed this meta-analysis in order to evaluate the relationship between ApoE gene polymorphism and susceptibility to vascular dementia in Chinese population by pooling data from all relevant case-control studies published domestically and abroad from January 1990 to May 2011. 18 case-control studies were selected. Meta-analysis results showed that the pooled OR value of vascular dementia subjects in Chinese population with ε4 allele carriers was 2.07 [95% CI (1.69, 2.53)], and the pooled OR value of vascular dementia subjects with E4/E4 genotype was 3.34 [95% CI (1.89, 5.88)]. These results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population. The subject with at least one ε4 allele or E4/E4 genotype has higher risk suffering from vascular dementia than others.[PUBLICATION ABSTRACT]
Author	Liu, Xu He, Zhiyi Deng, Shuming Li, Qu Zhu, Ruixia Li, Lei Liu, Fang
Author_xml	– sequence: 1 givenname: Xu surname: Liu fullname: Liu, Xu organization: Department of Neurology, First Affiliated Hospital of China Medical University – sequence: 2 givenname: Lei surname: Li fullname: Li, Lei organization: Department of Neurology, First Affiliated Hospital of China Medical University – sequence: 3 givenname: Fang surname: Liu fullname: Liu, Fang organization: Department of Neurology, First Affiliated Hospital of China Medical University – sequence: 4 givenname: Shuming surname: Deng fullname: Deng, Shuming organization: Department of Neurology, First Affiliated Hospital of China Medical University – sequence: 5 givenname: Ruixia surname: Zhu fullname: Zhu, Ruixia organization: Department of Neurology, First Affiliated Hospital of China Medical University – sequence: 6 givenname: Qu surname: Li fullname: Li, Qu organization: Department of Neurology, First Affiliated Hospital of China Medical University – sequence: 7 givenname: Zhiyi surname: He fullname: He, Zhiyi email: hezhiyi0301@sina.com organization: Department of Neurology, First Affiliated Hospital of China Medical University
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Snippet	Vascular dementia is the second common cause of dementia, only second to Alzheimer’s disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a... Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a...
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SubjectTerms	Alleles Alzheimer's disease Apolipoprotein E Apolipoprotein E4 Apolipoproteins E - genetics Asian Continental Ancestry Group - genetics China Data processing Dementia disorders Dementia, Vascular - genetics Dementias - Original Article Gene Frequency Gene polymorphism Genetic Predisposition to Disease Humans Medicine Medicine & Public Health Neurodegenerative diseases Neurology Neurosciences Polymorphism, Genetic Population genetics Psychiatry Reviews Risk factors Systematic review vascular dementia
Title	ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis
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