Free radicals enhance basal release of D-[3H]aspartate from cerebral cortical synaptosomes

• Published in: Journal of neurochemistry Vol. 62; no. 5; p. 1757
• Main Authors: Gilman, S C, Bonner, M J, Pellmar, T C
• Format: Journal Article
• Language: English
• Published: England 01.05.1994
• Subjects: Animals; Aspartic Acid - metabolism; Calcium - pharmacology; Cerebral Cortex - metabolism; Deferoxamine - pharmacology; Free Radicals - metabolism; Guinea Pigs; Hydrogen Peroxide - pharmacology; Iron - pharmacology; Male; Synaptosomes - drug effects; Synaptosomes - metabolism; Tritium

Excessive generation of free radicals has been implicated in several pathological conditions. We demonstrated previously that peroxide-generated free radicals decrease calcium-dependent high K(+)-evoked L[3H]-glutamate release from synaptosomes while increasing calcium-independent basal release. The...