TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke

• Published in: Stroke (1970) Vol. 47; no. 5; pp. 1180 - 1186
• Main Authors: Gallego-Fabrega, Cristina, Carrera, Caty, Reny, Jean-Luc, Fontana, Pierre, Slowik, Agnieszka, Pera, Joanna, Pezzini, Alessandro, Serrano-Heras, Gemma, Segura, Tomás, Martí-Fàbregas, Joan, Muiño, Elena, Cullell, Natalia, Montaner, Joan, Krupinski, Jerzy, Fernandez-Cadenas, Israel
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.05.2016
• Subjects: Aged; Aged, 80 and over; Brain Ischemia - genetics; Brain Ischemia - prevention & control; CpG Islands; DNA Methylation; Epigenesis, Genetic - genetics; Epigenomics; Female; Follow-Up Studies; Humans; Male; Middle Aged; Outcome Assessment (Health Care); Platelet Aggregation Inhibitors - therapeutic use; Recurrence; Stroke - genetics; Stroke - prevention & control; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; TNF Receptor-Associated Factor 3; clopidogrel; vascular resistance; aspirin; stroke; methylation

BACKGROUND AND PURPOSE—Clopidogrel is one of the most used antiplatelet drugs in patients with cardiovascular disease. However, 16% to 50% of patients have a high on-clopidogrel platelet reactivity and an increased risk of ischemic events. The pathogenesis of high on-treatment platelet reactivity in...