Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy
ABSTRACTCurrently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American...
Saved in:
| Published in | Neurosurgery Vol. 82; no. 2; pp. 237 - 246 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Copyright by the Congress of Neurological Surgeons
01.02.2018
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | ABSTRACTCurrently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subjectʼs death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (rs = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients. |
|---|---|
| AbstractList | Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (r
s
= 0.59,
P
= .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular–rotational acceleration–deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients. ABSTRACTCurrently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subjectʼs death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (rs = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients. Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (r s = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular–rotational acceleration–deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients. Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (rs = 0.59, P = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients. |
| Author | Bailes, Julian Ercoli, Linda M Hammers, Jennifer L Small, Gary W Huang, Sung-Cheng Lee, John Fitzsimmons, Robert P Merrill, David A Omalu, Bennet Satyamurthy, Nagichettiar Wong, Koon-Pong Barrio, Jorge R |
| AuthorAffiliation | Office of Chief Medical Examiner, City of New York, New York Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California Fitzsimmons Law Firm PLLC, Wheeling, West Virginia Department of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California Department of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois |
| AuthorAffiliation_xml | – name: Department of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois – name: Fitzsimmons Law Firm PLLC, Wheeling, West Virginia – name: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California – name: Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California – name: Department of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois – name: Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California – name: Office of Chief Medical Examiner, City of New York, New York – name: Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California ‡Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of Cali-fornia, Los Angeles, California §Depart-ment of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois ¶Department of Mole-cular and Medical Pharmacology, The David Geffen School of Medicine, Univer-sity of California, Los Angeles, California ||Office of Chief Medical Examiner, City of New York, New York #Department of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois Fitzsimmons Law Firm PLLC, Wheeling, West Virginia – name: 7 Fitzsimmons Law Firm PLLC, Wheeling, West Virginia – name: 3 Department of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois – name: 6 Department of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois – name: 1 Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California – name: 4 Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California – name: 5 Office of Chief Medical Examiner, City of New York, New York – name: 2 Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California |
| Author_xml | – sequence: 1 givenname: Bennet surname: Omalu fullname: Omalu, Bennet organization: Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California – sequence: 2 givenname: Gary surname: Small middlename: W fullname: Small, Gary W organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California – sequence: 3 givenname: Julian surname: Bailes fullname: Bailes, Julian organization: Department of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois – sequence: 4 givenname: Linda surname: Ercoli middlename: M fullname: Ercoli, Linda M organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California – sequence: 5 givenname: David surname: Merrill middlename: A fullname: Merrill, David A organization: Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California – sequence: 6 givenname: Koon-Pong surname: Wong fullname: Wong, Koon-Pong organization: Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California – sequence: 7 givenname: Sung-Cheng surname: Huang fullname: Huang, Sung-Cheng organization: Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California – sequence: 8 givenname: Nagichettiar surname: Satyamurthy fullname: Satyamurthy, Nagichettiar organization: Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California – sequence: 9 givenname: Jennifer surname: Hammers middlename: L fullname: Hammers, Jennifer L organization: Office of Chief Medical Examiner, City of New York, New York – sequence: 10 givenname: John surname: Lee fullname: Lee, John organization: Department of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois – sequence: 11 givenname: Robert surname: Fitzsimmons middlename: P fullname: Fitzsimmons, Robert P organization: Fitzsimmons Law Firm PLLC, Wheeling, West Virginia – sequence: 12 givenname: Jorge surname: Barrio middlename: R fullname: Barrio, Jorge R organization: Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29136240$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kV1rFDEYRoNU7LZ66a3kD8Tma7IzN8Ky3bVCqQuuKIiETJpxoplkyGSsc9Pfbuq0xQo1EELIcw7kfY7AgQ_eAPCS4NcEV-zEmzGG4cRPvwomnoAFKShHHHN8ABaY8BKxSnw-BEfD8B1jIviyfAYOaUWYoBwvwPUuDKkLMZkOrsYU-mFC6-AbGzuVbPAwNHDl8-sc-bJFpPy6PT292KHdZg8_aOUHaD1UcBtCqpVzcOfUZCL8ZFML120M3mq4j2q8EWq48dr0rXKhV6mdnoOnjXKDeXF7HoOP281-fYbO3799t16dI80xFUgUql4ys6x51XBWC6XzL5VoKkNxRStBC15hI1SluaiZYrpu6CUlWGdAsKZkx-DN7O3HujOX2vgUlZN9tJ2KkwzKyocv3rbyW_gphSgLjlkWvPpbcE_eTTIH2BzQuY4hmkZqm_6MMPuskwTLm77k3Jec-8oU-oe6Ez-WJ3P-Krhk4vDDjVcmytYol9pHGf4fBuclCGWIYlJimm8ob7JkvwF0c76u |
| CitedBy_id | crossref_primary_10_3390_molecules28083387 crossref_primary_10_1007_s13311_021_01028_3 crossref_primary_10_1016_j_mehy_2019_109422 crossref_primary_10_1186_s13024_025_00808_1 crossref_primary_10_1007_s00259_022_05963_x crossref_primary_10_1080_14680777_2023_2267790 crossref_primary_10_14423_SMJ_0000000000001022 crossref_primary_10_3389_fnint_2018_00051 crossref_primary_10_1016_j_biopsych_2021_06_005 crossref_primary_10_1016_j_nicl_2021_102665 crossref_primary_10_1089_neu_2019_6782 crossref_primary_10_4103_1673_5374_335824 crossref_primary_10_3233_JAD_180373 crossref_primary_10_1136_bjsports_2023_106890 crossref_primary_10_1080_14656566_2023_2224501 crossref_primary_10_1097_01_NT_0000538949_30949_05 crossref_primary_10_1038_s41380_020_0674_z crossref_primary_10_1039_D4CP03207A crossref_primary_10_1177_1012690219839909 crossref_primary_10_3389_fneur_2023_1239653 crossref_primary_10_1177_0954411920970812 crossref_primary_10_3233_JAD_171152 crossref_primary_10_1126_sciadv_aau3460 crossref_primary_10_1007_s00401_018_1902_3 crossref_primary_10_1055_s_0040_1713624 crossref_primary_10_3389_fneur_2018_00445 crossref_primary_10_1186_s40478_021_01197_4 crossref_primary_10_1007_s11831_021_09621_7 crossref_primary_10_3390_ijerph17155411 crossref_primary_10_1080_10668926_2019_1579121 crossref_primary_10_2967_jnumed_123_265593 crossref_primary_10_4103_1673_5374_314285 crossref_primary_10_4103_jfmpc_jfmpc_469_24 crossref_primary_10_1155_2018_7890269 crossref_primary_10_1016_j_biopha_2021_112602 crossref_primary_10_1016_j_brainres_2022_148176 crossref_primary_10_3389_fneur_2019_00209 crossref_primary_10_1093_braincomms_fcac019 crossref_primary_10_5607_en23008 crossref_primary_10_1016_j_inat_2021_101290 crossref_primary_10_1097_JSM_0000000000000778 crossref_primary_10_2967_jnumed_122_264404 crossref_primary_10_1007_s11102_019_00957_9 crossref_primary_10_1016_j_bioorg_2020_103857 crossref_primary_10_1016_j_cpet_2020_12_009 |
| Cites_doi | 10.1007/s00401-014-1349-0 10.1073/pnas.1409952112 10.1001/jamaneurol.2015.5015 10.1016/j.nucmedbio.2009.06.007 10.1016/S1474-4422(12)70142-4 10.1007/s00401-012-1055-8 10.31887/DCNS.2011.13.2/tmcallister 10.1111/bpa.12248 10.1093/brain/aws307 10.1097/NEN.0b013e3181ee7d85 10.1097/00019442-200201000-00004 10.3171/2013.7.JNS121822 10.1016/0022-3956(75)90026-6 10.1212/WNL.0b013e3182a55f7f 10.1007/s00401-015-1509-x 10.1097/NEN.0b013e3181a9d503 10.1111/j.2517-6161.1995.tb02031.x 10.1227/NEU.0b013e318212bc7b 10.1227/01.NEU.0000245601.69451.27 10.1227/01.NEU.0000163407.92769.ED 10.1111/nan.12323 10.1159/000122586 10.1021/ja9543356 10.1016/S0076-6879(06)12010-8 10.3233/JAD-122434 10.1056/NEJMoa054625 10.1056/NEJMcp064645 10.1007/s11307-006-0061-4 10.1007/s00401-015-1515-z 10.1016/j.jagp.2012.11.019 10.1007/s00401-015-1496-y 10.1212/WNL.41.4.479 |
| ContentType | Journal Article |
| Copyright | Copyright © by the Congress of Neurological Surgeons Copyright © 2017 by the Congress of Neurological Surgeons. Copyright © 2017 by the Congress of Neurological Surgeons 2018 |
| Copyright_xml | – notice: Copyright © by the Congress of Neurological Surgeons – notice: Copyright © 2017 by the Congress of Neurological Surgeons. – notice: Copyright © 2017 by the Congress of Neurological Surgeons 2018 |
| DBID | AAYXX CITATION NPM 5PM |
| DOI | 10.1093/neuros/nyx536 |
| DatabaseName | CrossRef PubMed PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed |
| DatabaseTitleList | CrossRef PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1524-4040 |
| EndPage | 246 |
| ExternalDocumentID | PMC6685403 29136240 10_1093_neuros_nyx536 10.1093/neuros/nyx536 00006123-201802000-00017 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: P01 AG025831 – fundername: ; – fundername: ; ; grantid: P01-AG025831; M01-RR00865 |
| GroupedDBID | --- .-D .3C .55 .GJ .Z2 01R 0R~ 123 1TH 354 3O- 40H 48X 4Q1 4Q2 4Q3 53G 5RE 5VS 71W 77Y 7O~ 7X7 88E 8FI 8FJ A9M AAAAV AAAXR AAGIX AAHPQ AAIQE AAJQQ AAKAS AAPQZ AAPXW AAQKA AAQOH AAQQT AARTV AASCR AASOK AASXQ AAUQX AAVAP AAYEP ABASU ABDIG ABHFT ABJNI ABLJU ABOCM ABPPZ ABPTD ABPXF ABUWG ABZAD ABZZY ACDDN ACFRR ACGFO ACGFS ACILI ACLDA ACOAL ACUTJ ACWRI ACXJB ACXNZ ACZKN ADBBV ADBIZ ADFPA ADGZP ADHKW ADHPY ADRTK ADZCM AE3 AE6 AEETU AEMDU AENEX AENZO AETBJ AEWNT AFBFQ AFDTB AFKRA AFOFC AFTRI AFUWQ AGINI AGINJ AGKRT AHMBA AHOMT AHQNM AHRYX AHVBC AIZYK AJCLO AJNWD AJNYG AJZMW AKCTQ ALIPV ALKUP ALMA_UNASSIGNED_HOLDINGS AMNEI AOQMC APIBT APJGH AQDSO AQKUS ASAOO ATDFG BAYMD BENPR BOYCO BPHCQ BS7 BTRTY BVXVI BYPQX C45 CCPQU CDBKE CS3 DAKXR E.X EBS EEVPB EIHJH EJD ELUNK ENERS ERAAH EX3 F2K F2L F2M F2N F5P FCALG FECEO FL- FLUFQ FOEOM FOTVD FQBLK FW0 FYUFA GAUVT GJXCC H0~ H13 HLJTE HMCUK HZ~ IAO IHR INH INR IN~ IPNFZ J5H JF7 JF9 JG8 JK3 JK8 JXSIZ K8S KD2 KMI KSI KSN L-C L7B LMP M18 M1P MBLQV MBTAY MHKGH N4W N9A NOYVH NVLIB N~7 N~B N~M O9- OAG OAH OBH OCUKA ODA ODMLO OHH OL1 OLB OLG OLH OLU OLV OLY OLZ ORVUJ OVD OWU OWV OWW OWX OWY OWZ P-K P2P PAFKI PEELM PHGZM PHGZT PQQKQ PROAC PSQYO R58 RIG RLZ ROZ RUSNO RXW S4R SJN TEORI TJX UKHRP V2I VVN W3M WOQ WOW X3V X3W X7M XXN XYM YAYTL YFH YKOAZ YOC YXANX ZFV ZGI ZXP ZY1 AAYXX CITATION ACIJW NPM YCJ 5PM ADSXY PJZUB PPXIY |
| ID | FETCH-LOGICAL-c4026-65ab73e7b49f43b6ac524a6f9e20929625490e6a9c46b3a3cbf2d210cb4963f83 |
| ISSN | 0148-396X |
| IngestDate | Thu Aug 21 18:34:52 EDT 2025 Thu Apr 03 07:04:28 EDT 2025 Thu Apr 24 22:59:05 EDT 2025 Thu Jul 03 08:30:38 EDT 2025 Fri May 16 03:50:08 EDT 2025 Fri May 16 03:50:28 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | [F-18]FDDNP-PET Football player Autopsy CTE Antemortem |
| Language | English |
| License | Copyright © 2017 by the Congress of Neurological Surgeons. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4026-65ab73e7b49f43b6ac524a6f9e20929625490e6a9c46b3a3cbf2d210cb4963f83 |
| PMID | 29136240 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6685403 pubmed_primary_29136240 crossref_citationtrail_10_1093_neuros_nyx536 crossref_primary_10_1093_neuros_nyx536 wolterskluwer_health_10_1093_neuros_nyx536 wolterskluwer_health_00006123-201802000-00017 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-February |
| PublicationDateYYYYMMDD | 2018-02-01 |
| PublicationDate_xml | – month: 02 year: 2018 text: 2018-February |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Neurosurgery |
| PublicationTitleAlternate | Neurosurgery |
| PublicationYear | 2018 |
| Publisher | Copyright by the Congress of Neurological Surgeons Oxford University Press |
| Publisher_xml | – name: Copyright by the Congress of Neurological Surgeons – name: Oxford University Press |
| References | Bailes (bib30-20231011) 2013; 119 Reams (bib6-20231011) 2016; 73 Folstein (bib7-20231011) 1975; 12 Smid (bib25-20231011) 2013; 36 McKee (bib28-20231011) 2009; 68 McKee (bib17-20231011) 2016; 131 Shoghi-Jadid (bib2-20231011) 2002; 10 Kepe (bib12-20231011) 2006; 412 Crary (bib18-20231011) 2014; 128 Clark (bib34-20231011) 2012; 11 Robinson (bib35-20231011) 2013; 125 Small (bib11-20231011) 2006; 355 McKee (bib23-20231011) 2010; 69 Armstrong (bib24-20231011) 2016; 43 Stern (bib32-20231011) 2013; 81 Tantawy (bib13-20231011) 2009; 36 Schnaider Beeri (bib33-20231011) 2008; 25 Jacobson (bib3-20231011) 1996; 118 Ling (bib16-20231011) 2015; 130 Omalu (bib20-20231011) 2011; 69 McKee (bib27-20231011) 2015; 25 Ropper (bib29-20231011) 2007; 356 Barrio (bib1-20231011) 2015; 112 Omalu (bib21-20231011) 2006; 59 Omalu (bib26-20231011) 2005; 57 Benjamini (bib15-20231011) 1995; 57 Kovacs (bib19-20231011) 2016; 131 Mirra (bib14-20231011) 1991; 41 McAllister (bib31-20231011) 2011; 13 Small (bib4-20231011) 2013; 21 Liu (bib9-20231011) 2007; 9 McKee (bib22-20231011) 2013; 136 |
| References_xml | – volume: 128 start-page: 755 issue: 6 year: 2014 ident: bib18-20231011 article-title: Primary age-related tauopathy (PART): a common pathology associated with human aging publication-title: Acta Neuropathol doi: 10.1007/s00401-014-1349-0 – volume: 112 start-page: E2039 issue: 16 year: 2015 ident: bib1-20231011 article-title: In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1409952112 – volume: 73 start-page: 743 issue: 6 year: 2016 ident: bib6-20231011 article-title: A clinical approach to the diagnosis of traumatic encephalopathy syndrome: a review publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2015.5015 – volume: 36 start-page: 931 issue: 8 year: 2009 ident: bib13-20231011 article-title: [(18)F]Fallypride dopamine D2 receptor studies using delayed microPET scans and a modified Logan plot publication-title: Nucl Med Biol doi: 10.1016/j.nucmedbio.2009.06.007 – volume: 11 start-page: 669 issue: 8 year: 2012 ident: bib34-20231011 article-title: Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(12)70142-4 – volume: 125 start-page: 121 issue: 1 year: 2013 ident: bib35-20231011 article-title: TDP-43 skeins show properties of amyloid in a subset of ALS cases publication-title: Acta Neuropathol doi: 10.1007/s00401-012-1055-8 – volume: 13 start-page: 287 issue: 3 year: 2011 ident: bib31-20231011 article-title: Neurobiological consequences of traumatic brain injury publication-title: Dialogues Clin Neurosci doi: 10.31887/DCNS.2011.13.2/tmcallister – volume: 25 start-page: 350 issue: 3 year: 2015 ident: bib27-20231011 article-title: The neuropathology of chronic traumatic encephalopathy publication-title: Brain Pathol doi: 10.1111/bpa.12248 – volume: 136 start-page: 43 issue: Pt 1 year: 2013 ident: bib22-20231011 article-title: The spectrum of disease in chronic traumatic encephalopathy publication-title: Brain doi: 10.1093/brain/aws307 – volume: 69 start-page: 918 issue: 9 year: 2010 ident: bib23-20231011 article-title: TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e3181ee7d85 – volume: 10 start-page: 24 issue: 1 year: 2002 ident: bib2-20231011 article-title: Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease publication-title: Am J Geriatr Psychiatry doi: 10.1097/00019442-200201000-00004 – volume: 119 start-page: 1235 issue: 5 year: 2013 ident: bib30-20231011 article-title: Role of subconcussion in repetitive mild traumatic brain injury publication-title: J Neurosurg doi: 10.3171/2013.7.JNS121822 – volume: 12 start-page: 189 issue: 3 year: 1975 ident: bib7-20231011 article-title: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician publication-title: J Psychiatr Res doi: 10.1016/0022-3956(75)90026-6 – volume: 81 start-page: 1122 issue: 13 year: 2013 ident: bib32-20231011 article-title: Clinical presentation of chronic traumatic encephalopathy publication-title: Neurology doi: 10.1212/WNL.0b013e3182a55f7f – volume: 131 start-page: 87 issue: 1 year: 2016 ident: bib19-20231011 article-title: Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy publication-title: Acta Neuropathol doi: 10.1007/s00401-015-1509-x – volume: 68 start-page: 709 issue: 7 year: 2009 ident: bib28-20231011 article-title: Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0b013e3181a9d503 – volume: 57 start-page: 289 issue: 1 year: 1995 ident: bib15-20231011 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J R Statist Soc B doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 69 start-page: 173 issue: 1 year: 2011 ident: bib20-20231011 article-title: Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes publication-title: Neurosurgery doi: 10.1227/NEU.0b013e318212bc7b – volume: 59 start-page: 1086 issue: 5 year: 2006 ident: bib21-20231011 article-title: Chronic traumatic encephalopathy in a national football league player: part II publication-title: Neurosurgery doi: 10.1227/01.NEU.0000245601.69451.27 – volume: 57 start-page: 128 issue: 1 year: 2005 ident: bib26-20231011 article-title: Chronic traumatic encephalopathy in a National Football League player publication-title: Neurosurgery doi: 10.1227/01.NEU.0000163407.92769.ED – volume: 43 start-page: 154 issue: 2 year: 2016 ident: bib24-20231011 article-title: A quantitative study of tau pathology in eleven cases of chronic traumatic encephalopathy publication-title: Neuropathol Appl Neurobiol doi: 10.1111/nan.12323 – volume: 25 start-page: 392 issue: 5 year: 2008 ident: bib33-20231011 article-title: Clinical dementia rating performed several years prior to death predicts regional Alzheimer's neuropathology publication-title: Dement Geriatr Cogn Disord doi: 10.1159/000122586 – volume: 118 start-page: 5572 year: 1996 ident: bib3-20231011 article-title: 1,1-dicyano-2-1[dimethylamino)naphthalen-2-y1]propene (DDNP): a solvent polarity and viscosity sensitive fluorophore for fluorescence microscopy publication-title: J Am Chem Soc doi: 10.1021/ja9543356 – volume: 412 start-page: 144 year: 2006 ident: bib12-20231011 article-title: Visualizing pathology deposits in the living brain of patients with Alzheimer's disease publication-title: Methods Enzymol doi: 10.1016/S0076-6879(06)12010-8 – volume: 36 start-page: 261 issue: 2 year: 2013 ident: bib25-20231011 article-title: Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging publication-title: J Alzheimers Dis doi: 10.3233/JAD-122434 – volume: 355 start-page: 2652 issue: 25 year: 2006 ident: bib11-20231011 article-title: PET of brain amyloid and tau in mild cognitive impairment publication-title: N Engl J Med doi: 10.1056/NEJMoa054625 – volume: 356 start-page: 166 issue: 2 year: 2007 ident: bib29-20231011 article-title: Clinical practice. Concussion publication-title: N Engl J Med doi: 10.1056/NEJMcp064645 – volume: 9 start-page: 6 issue: 1 year: 2007 ident: bib9-20231011 article-title: High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration publication-title: Mol Imaging Biol doi: 10.1007/s11307-006-0061-4 – volume: 131 start-page: 75 issue: 1 year: 2016 ident: bib17-20231011 article-title: The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy publication-title: Acta Neuropathol doi: 10.1007/s00401-015-1515-z – volume: 21 start-page: 138 issue: 2 year: 2013 ident: bib4-20231011 article-title: PET scanning of brain tau in retired national football league players: preliminary findings publication-title: Am J Geriatr Psychiatry doi: 10.1016/j.jagp.2012.11.019 – volume: 130 start-page: 891 issue: 6 year: 2015 ident: bib16-20231011 article-title: Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases publication-title: Acta Neuropathol doi: 10.1007/s00401-015-1496-y – volume: 41 start-page: 479 issue: 4 year: 1991 ident: bib14-20231011 article-title: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease publication-title: Neurology doi: 10.1212/WNL.41.4.479 |
| SSID | ssj0016478 |
| Score | 2.4682925 |
| Snippet | ABSTRACTCurrently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be... Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental... |
| SourceID | pubmedcentral pubmed crossref wolterskluwer |
| SourceType | Open Access Repository Index Database Enrichment Source Publisher |
| StartPage | 237 |
| SubjectTerms | Special |
| Title | Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00006123-201802000-00017 https://www.ncbi.nlm.nih.gov/pubmed/29136240 https://pubmed.ncbi.nlm.nih.gov/PMC6685403 |
| Volume | 82 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLVK94KEEIiv8iU_MB4YZontuMnjSlsmJKoKddIkhCI7S7RqXTKtqWA88GP4pdwbu2kzgjR4iaLUsZLe45vr63uOCXnFM_B4JvCZDlXGpIwypqVJmMpUJqT0NPeRnPxpog6P5Mfj4LjT-bVVtbQqzbvkRyuv5H-sCtfArsiS_QfL1p3CBTgH-8IRLAzHG9kYd9o9r6pl9w5WZXGxvGLI4Js7PmIVZeZVLS022Q0GY-aHu8FwPBxOpmw6msHQ1raSXO-Ni6I0uFA9XWiIw8FfID3JaueiBvrKiruOkOZ4qhcF7mXcWBOudD6WWzRrzN2e68WqwlDF_9nkc7Rd7viARXt1mmeg524LbqRtb3A7ugS4zusUgsvgulyFH67LmxvpSxFVexfC18e5XC5hFmtFm9Y-OeRb2OPbDtZKxLhvNbfpyz8-A1YiyyqC4snV90C0CG5f-xDW5Yl2YV7EtoPY3n6L7HCYivAu2RmMJtPP9VoVsnVtoax9N6fkCh3s2w72bQeNyKcOd66X4t75VmCZxPKsYklsxTqze-Sum6TQA4u4-6ST5g_Izw3aaBvaaJHRDdroF8Ta1xpptEIanedU0zXSqEUaRaRRhzRaI402kfaQHI1Hs_eHzO3ewRIJE3umAm36Iu0bGP9SGKUTMLRWWZRyD2JyhZkJL1U6SqQyQovEZPyE-14CNyiRheIR6eZFnj4h9IQnup-pSGSpkFoL8CuRQBUpYQx4FNEjb9f_bJw4aXvcYWURt1qyR17XzS-spsvfGj621qmb8ciHiE96PdJv2K1ugGrtzV_y-Wml2q5UCLMjeFbWsHBs-c6x56SQGI4bby344Pd75E1r-9YHfnrTN3tGbm_G53PSLS9X6QuIrkvz0sH7NxsB2Wc |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Postmortem+Autopsy-Confirmation+of+Antemortem+%5BF-18%5DFDDNP-PET+Scans+in+a+Football+Player+With+Chronic+Traumatic+Encephalopathy&rft.jtitle=Neurosurgery&rft.au=Omalu%2C+Bennet&rft.au=Small%2C+Gary+W&rft.au=Bailes%2C+Julian&rft.au=Ercoli%2C+Linda+M&rft.date=2018-02-01&rft.issn=0148-396X&rft.eissn=1524-4040&rft.volume=82&rft.issue=2&rft.spage=237&rft.epage=246&rft_id=info:doi/10.1093%2Fneuros%2Fnyx536&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_neuros_nyx536 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0148-396X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0148-396X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0148-396X&client=summon |