New aspects on prostaglandin D synthases

• Published in: Nihon yakurigaku zasshi Vol. 110 Suppl 1; p. 56P
• Main Author: Urade, Y
• Format: Journal Article
• Language: Japanese
• Published: Japan 1997
• Subjects: Animals; Binding Sites; Biological Transport; Carrier Proteins; Central Nervous System - enzymology; Glutathione - metabolism; Glutathione Transferase; Humans; Immune System - enzymology; Intramolecular Oxidoreductases - classification; Intramolecular Oxidoreductases - pharmacology; Intramolecular Oxidoreductases - physiology; Lipocalins; Prostaglandin D2 - physiology; Tretinoin - metabolism

Prostaglandin (PG) D2 is a major prostanoid produced in the central nervous system and mast cells, acting as a neuromodulator and an allergic and inflammatory mediator. PGD2 is readily dehydrated to produce PGs of the J series, such as PGJ2, delta 12-PGJ2, and 15-deoxy-delta 12, 14-PGJ2. We identifi...