Montelukast for Migraine Prophylaxis: A Randomized, Double-Blind, Placebo-Controlled Study

• Published in: Headache Vol. 44; no. 6; pp. 581 - 586
• Main Authors: Brandes, Jan L., Visser, W. Hester, Farmer, Mildred V., Schuhl, Amy L., Malbecq, William, Vrijens, France, Lines, Christopher R., Reines, Scott A.
• Format: Journal Article
• Language: English
• Published: 350 Main Street , Malden , MA 02148 , USA Blackwell Publishing, Inc 01.06.2004; Blackwell
• Subjects: Acetates - therapeutic use; Adult; Biological and medical sciences; Double-Blind Method; Female; Humans; Leukotriene Antagonists - therapeutic use; Male; Medical sciences; migraine; Migraine Disorders - prevention & control; montelukast; Neurology; prophylaxis; Quinolines - therapeutic use; treatment; Treatment Outcome; Vascular diseases and vascular malformations of the nervous system; Headache; Nervous system diseases; Leukotriene receptor; Migraine; Montelukast; Cardiovascular disease; Leukotriene D4; Leukotriene E4; Antiasthma agent; prophylaxis; Cerebral disorder; Vascular disease; Prevention; Pain; Treatment; Central nervous system disease; Double blind study; Leukotriene antagonist; Neurological disorder; Cerebrovascular disease

Objective.—To evaluate the efficacy and tolerability of montelukast 20 mg in the prophylactic treatment of migraine. Background.—A previous small open‐label study in migraine patients suggested prophylactic efficacy for montelukast, an antagonist of the cysteinyl leukotriene receptor that is used in...