The metabolic syndrome alters the miRNA signature of porcine adipose tissue‐derived mesenchymal stem cells

• Published in: Cytometry. Part A Vol. 93; no. 1; pp. 93 - 103
• Main Authors: Meng, Yu, Eirin, Alfonso, Zhu, Xiang‐Yang, Tang, Hui, Chanana, Pritha, Lerman, Amir, Van Wijnen, Andre J., Lerman, Lilach O.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018
• Subjects: Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; Autografts; Cytometry; Diabetes mellitus; Disease Models, Animal; Enrichment; extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; Female; Fra1 protein; Gene sequencing; Genes; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mesenchymal Stem Cells - pathology; Mesenchyme; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; microRNA; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Receptors; Rhodopsin; Ribonucleic acid; RNA; Stem cell transplantation; Stem cells; Sus scrofa; Swine; Transcription factors; Translational Medical Research; Transplantation; metabolic syndrome; microRNA; extracellular vesicles; mesenchymal stem cells

Autologous transplantation of mesenchymal stem cells (MSCs) is a viable option for the treatment of several diseases. Evidence indicates that MSCs release extracellular vesicles (EVs) and that EVs shuttle miRNAs to damaged parenchymal cells to activate an endogenous repair program. We hypothesize th...