Pharmacokinetics of ketoprofen enantiomers after intravenous administration of racemate in camels: effect of gender

• Published in: Journal of veterinary pharmacology and therapeutics Vol. 23; no. 3; pp. 137 - 143
• Main Authors: Al Katheeri, N. A., Wasfi, I. A., Lambert, M., Saeed, A., Khan, I. A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.06.2000
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Area Under Curve; Camelus; Chromatography, High Pressure Liquid; Female; Half-Life; Injections, Intravenous; Ketoprofen - blood; Ketoprofen - metabolism; Ketoprofen - pharmacokinetics; Male; Metabolic Clearance Rate; Protein Binding; Sex Factors; Stereoisomerism

The pharmacokinetics of ketoprofen (KP) enantiomers were studied in ten female and eight male camels after a single intravenous dose (2.0 mg/kg) of racemic KP. A high performance liquid chromatographic (HPLC) method was developed for the quantitation of the R‐ and S‐enantiomers without derivatizatio...