Gene expression signatures in chronic and aggressive periodontitis: a pilot study
This pilot study examined gene expression signatures in pathological gingival tissues of subjects with chronic or aggressive periodontitis, and explored whether new subclasses of periodontitis can be identified based on gene expression profiles. A total of 14 patients, seven with chronic and seven w...
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Published in | European journal of oral sciences Vol. 112; no. 3; pp. 216 - 223 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Munksgaard International Publishers
01.06.2004
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Abstract | This pilot study examined gene expression signatures in pathological gingival tissues of subjects with chronic or aggressive periodontitis, and explored whether new subclasses of periodontitis can be identified based on gene expression profiles. A total of 14 patients, seven with chronic and seven with aggressive periodontitis, were examined with respect to clinical periodontal status, composition of subgingival bacterial plaque assessed by checkerboard hybridizations, and levels of serum IgG antibodies to periodontal bacteria assayed by checkerboard immunoblotting. In addition, at least two pathological pockets/patient were biopsied, processed for RNA extraction, amplification and labeling, and used to study gene expression using Affymetrix U‐133 A arrays. Based on a total of 35 microarrays, no significantly different gene expression profiles appeared to emerge between chronic and aggressive periodontitis. However, a de novo grouping of the 14 subjects into two fairly robust clusters was possible based on similarities in gene expression. These two groups had similar clinical periodontal status and subgingival bacterial profiles, but differed significantly with respect to serum IgG levels against the important periodontal pathogens Porphyromonas gingivalis, Tannerella forsythensis and Campylobacter rectus. These early data point to the usefulness of gene expression profiling techniques in the identification of subclasses of periodontitis with common pathobiology. |
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AbstractList | This pilot study examined gene expression signatures in pathological gingival tissues of subjects with chronic or aggressive periodontitis, and explored whether new subclasses of periodontitis can be identified based on gene expression profiles. A total of 14 patients, seven with chronic and seven with aggressive periodontitis, were examined with respect to clinical periodontal status, composition of subgingival bacterial plaque assessed by checkerboard hybridizations, and levels of serum IgG antibodies to periodontal bacteria assayed by checkerboard immunoblotting. In addition, at least two pathological pockets/patient were biopsied, processed for RNA extraction, amplification and labeling, and used to study gene expression using Affymetrix U-133 A arrays. Based on a total of 35 microarrays, no significantly different gene expression profiles appeared to emerge between chronic and aggressive periodontitis. However, a de novo grouping of the 14 subjects into two fairly robust clusters was possible based on similarities in gene expression. These two groups had similar clinical periodontal status and subgingival bacterial profiles, but differed significantly with respect to serum IgG levels against the important periodontal pathogens Porphyromonas gingivalis, Tannerella forsythensis and Campylobacter rectus. These early data point to the usefulness of gene expression profiling techniques in the identification of subclasses of periodontitis with common pathobiology. This pilot study examined gene expression signatures in pathological gingival tissues of subjects with chronic or aggressive periodontitis, and explored whether new subclasses of periodontitis can be identified based on gene expression profiles. A total of 14 patients, seven with chronic and seven with aggressive periodontitis, were examined with respect to clinical periodontal status, composition of subgingival bacterial plaque assessed by checkerboard hybridizations, and levels of serum IgG antibodies to periodontal bacteria assayed by checkerboard immunoblotting. In addition, at least two pathological pockets/patient were biopsied, processed for RNA extraction, amplification and labeling, and used to study gene expression using Affymetrix U‐133 A arrays. Based on a total of 35 microarrays, no significantly different gene expression profiles appeared to emerge between chronic and aggressive periodontitis. However, a de novo grouping of the 14 subjects into two fairly robust clusters was possible based on similarities in gene expression. These two groups had similar clinical periodontal status and subgingival bacterial profiles, but differed significantly with respect to serum IgG levels against the important periodontal pathogens Porphyromonas gingivalis, Tannerella forsythensis and Campylobacter rectus . These early data point to the usefulness of gene expression profiling techniques in the identification of subclasses of periodontitis with common pathobiology. |
Author | Fine, James B. Abron, Armin Qin, Jie Yang, Jun Verbitsky, Miguel Pavlidis, Paul Picolos, Doros Papapanou, Panos N. |
Author_xml | – sequence: 1 givenname: Panos N. surname: Papapanou fullname: Papapanou, Panos N. organization: Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, USA – sequence: 2 givenname: Armin surname: Abron fullname: Abron, Armin organization: Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, USA – sequence: 3 givenname: Miguel surname: Verbitsky fullname: Verbitsky, Miguel organization: Genome Center, Columbia University, New York, USA – sequence: 4 givenname: Doros surname: Picolos fullname: Picolos, Doros organization: Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, USA – sequence: 5 givenname: Jun surname: Yang fullname: Yang, Jun organization: Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, USA – sequence: 6 givenname: Jie surname: Qin fullname: Qin, Jie organization: Genome Center, Columbia University, New York, USA – sequence: 7 givenname: James B. surname: Fine fullname: Fine, James B. organization: Division of Periodontics, Section of Oral and Diagnostic Sciences, School of Dental and Oral Surgery, Columbia University, New York, USA – sequence: 8 givenname: Paul surname: Pavlidis fullname: Pavlidis, Paul organization: Genome Center, Columbia University, New York, USA |
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Cites_doi | 10.1111/j.1558-5646.1985.tb00420.x 10.1111/j.1399-302X.1997.tb00395.x 10.1038/ng1061 10.1073/pnas.211566398 10.1034/j.1600-0757.2002.03002.x 10.1902/annals.1999.4.1.38 10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L 10.1902/annals.1999.4.1.1 10.1038/35000501 10.1038/nm0103-9a 10.1093/bioinformatics/16.10.906 10.1902/annals.1999.4.1.53 10.1902/jop.2000.71.6.885 10.1016/S0736-5748(02)00041-2 10.1002/jnr.10351 10.1073/pnas.95.25.14863 10.1006/clim.2002.5227 10.1038/35021093 10.1902/annals.1999.4.1.64 10.1126/science.286.5439.531 10.1038/ng1038 10.1038/415530a 10.1038/415436a 10.1056/NEJMra012479 10.1056/NEJMoa021967 10.1016/S0002-9440(10)63696-6 |
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SubjectTerms | Acute Disease Adolescent Adult Aggregatibacter actinomycetemcomitans - genetics Aggressive Periodontitis - genetics Aggressive Periodontitis - immunology Aggressive Periodontitis - microbiology Antibodies, Bacterial - genetics Bacteroides - genetics Campylobacter rectus - genetics Chronic Disease classification Dental Plaque - microbiology Dentistry DNA, Bacterial - analysis Female gene expression Gene Expression Profiling Humans Immunoglobulin G - blood Immunoglobulin G - genetics Male microarray Oligonucleotide Array Sequence Analysis periodontitis Periodontitis - genetics Periodontitis - immunology Periodontitis - microbiology Pilot Projects Porphyromonas gingivalis - genetics |
Title | Gene expression signatures in chronic and aggressive periodontitis: a pilot study |
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