The antineoplastic effect of methylprednisolone pulse therapy in two patients with glucocorticoid receptor-positive glioblastoma multiforme

• Published in: Acta neurologica Scandinavica Vol. 77; no. 1; p. 74
• Main Authors: Ellemann, K, Bollinger, B, Soelberg Soerensen, P, Zeeberg, I
• Format: Journal Article
• Language: English
• Published: Denmark 01.03.1988
• Subjects: Adult; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Brain Neoplasms - analysis; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - drug therapy; Female; Glioblastoma - analysis; Glioblastoma - diagnostic imaging; Glioblastoma - drug therapy; Humans; Male; Methylprednisolone - administration & dosage; Methylprednisolone - therapeutic use; Receptors, Glucocorticoid - analysis; Time Factors; Tomography, X-Ray Computed

Glucocorticoids in high concentrations inhibit in vitro the growth rate of glioblastoma multiforme. This presupposes the presence of glucocorticoid receptors in the cytoplasma. Glucocorticoid receptor positive patients with histological glioblastoma multiforme were postoperatively treated with high...