Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 134B; no. 1; pp. 20 - 24
• Main Authors: Reuter, M., Hennig, J.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.04.2005
• Subjects: 5-HT; Adult; Aggression; Amino Acid Substitution; Analysis of Variance; Female; Genetic Predisposition to Disease - genetics; Genetic Predisposition to Disease - psychology; Genotype; Hostility; Humans; Male; nicotine addiction; personality; Personality - genetics; pleiotropic effect; Polymorphism, Genetic; Smoking - genetics; Tobacco Use Disorder - genetics; TPH1 A779C polymorphism; Tryptophan Hydroxylase - genetics

Recent studies from molecular genetics have suggested an association between the tryptophan hydroxylase 1 (TPH1) gene and nicotine addiction indicating a dysfunction of the serotonergic (5‐HT) system in smoking behavior. In a sample of 252 healthy subjects, a significant association between variatio...