Efficacy and safety of Bio 3D conduits composed of human umbilical cord–derived mesenchymal stromal cells: A proof-of-concept study in a canine ulnar nerve defect model

• Published in: Cell transplantation Vol. 34; p. 9636897251361711
• Main Authors: Fujita, Kazuaki, Ikeguchi, Ryosuke, Aoyama, Tomoki, Noguchi, Takashi, Yoshimoto, Koichi, Sakamoto, Daichi, Iwai, Terunobu, Miyamoto, Tetsuya, Miyazaki, Yudai, Akieda, Shizuka, Nagamura-Inoue, Tokiko, Nagamura, Fumitaka, Nakayama, Koichi, Matsuda, Shuichi
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.2025; Sage Publications Ltd; SAGE Publishing
• Subjects: Animals; Cell migration; Disease Models, Animal; Dogs; Humans; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Morbidity; Myelin; Nerve Regeneration - physiology; Original; Peripheral nerves; Proof of Concept Study; Regeneration; Stem cell transplantation; Stromal cells; Tissue Scaffolds - chemistry; Ulnar Nerve - injuries; Ulnar Nerve - pathology; Umbilical cord; Umbilical Cord - cytology; peripheral nerve injury; Bio 3D conduit; nerve regeneration; mesenchymal stromal cell; preclinical study; regenerative medicine

Peripheral nerve injuries involving nerve defects remain challenging to treat. Although autologous nerve grafting is considered the gold standard, it has notable limitations, including donor site morbidity. To address this, we developed a scaffold-free Bio 3D conduit composed of human umbilical cord...