Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

• Published in: Wellcome open research Vol. 8; p. 146
• Main Authors: Padalino, Gilda, Celatka, Cassandra A, Rienhoff, Jr, Hugh Y, Kalin, Jay H, Cole, Philip A, Lassalle, Damien, Forde-Thomas, Josephine, Chalmers, Iain W, Brancale, Andrea, Grunau, Christoph, Hoffmann, Karl F
• Format: Journal Article
• Language: English
• Published: England F1000 Research Limited 2023; Wellcome
• Subjects: anthelmintics; ATAC-seq; eng; epigenetics; Lysine Specific Demethylase 1; Lysine Specific Demethylase 1; ATAC-seq; epigenetics; anthelmintics

: , a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigenetic processes. As inhibition of epigenetic machinery components impairs key transitions th...