Alzheimer's Prevention Initiative: A Proposal to Evaluate Presymptomatic Treatments as Quickly as Possible

• Published in: Biomarkers in medicine Vol. 4; no. 1; pp. 3 - 14
• Main Authors: Reiman, Eric M, Langbaum, Jessica BS, Tariot, Pierre N
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.02.2010
• Subjects: Alzheimer Disease - diagnosis; Alzheimer Disease - drug therapy; Alzheimer Disease - prevention & control; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Apolipoprotein E4 - genetics; Biomarkers; Biomarkers - cerebrospinal fluid; Disease prevention; Humans; Magnetic Resonance Imaging; Medical research; Medical treatment; Nootropic Agents - therapeutic use; Positron-Emission Tomography; Public Policy; Randomized Controlled Trials as Topic; tau Proteins - cerebrospinal fluid; United States; United States; clinical trial; apolipoprotein; amyloid; genetics; surrogate marker; MRI; presenilin; biomarker; PET; public policy

Now is the time to launch the era of Alzheimer's disease (AD) prevention research, establish the methods and infrastructure to rapidly evaluate presymptomatic AD treatments and evaluate them rigorously and rapidly in randomized clinical trials. This article is a call to arms. It contends that t...