Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries

• Published in: Science translational medicine Vol. 13; no. 582
• Main Authors: Wang, Tao, Wagner, Andrea, Gehwolf, Renate, Yan, Wenjin, Passini, Fabian S, Thien, Christine, Weissenbacher, Nadja, Lin, Zhen, Lehner, Christine, Teng, Huajian, Wittner, Claudia, Zheng, Qiujian, Dai, Jin, Ni, Ming, Wang, Allan, Papadimitriou, John, Leys, Toby, Tuan, Rocky S, Senck, Sasha, Snedeker, Jess G, Tempfer, Herbert, Jiang, Qing, Zheng, Ming H, Traweger, Andreas
• Format: Journal Article
• Language: English
• Published: United States 24.02.2021
• Subjects: Animals; Genetic Predisposition to Disease; Homeostasis; Humans; Ligaments; Mice; Mice, Knockout; Osteonectin - genetics; Tendons - physiology

Tendons and tendon interfaces have a very limited regenerative capacity, rendering their injuries clinically challenging to resolve. Tendons sense muscle-mediated load; however, our knowledge on how loading affects tendon structure and functional adaption remains fragmentary. Here, we provide eviden...