Interactions of Phytoestrogens with Estrogen Receptors α and β (III). Estrogenic Activities of Soy Isoflavone Aglycones and Their Metabolites Isolated from Human Urine

• Published in: Biological & pharmaceutical bulletin Vol. 27; no. 2; pp. 185 - 188
• Main Authors: Tsuchihashi, Ryota, Aomori, Tohru, Okabe, Hikaru, Hirose, Toshiharu, Kinjo, Junei, Nohara, Toshihiro, Morito, Keiko, Nagao, Tsuneatsu, Masamune, Yukito
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.02.2004
• Subjects: beta-Galactosidase - biosynthesis; Binding, Competitive; Cell Line, Tumor; Cell Proliferation - drug effects; Enzyme Induction; Estrogen Receptor alpha - drug effects; Estrogen Receptor alpha - metabolism; Estrogen Receptor beta - drug effects; Estrogen Receptor beta - metabolism; hER binding; hER-dependent MCF-7 cell growth; hER-dependent β-galactosidase induction; human estrogen receptor (hER); Humans; isoflavone metabolite; Isoflavones - pharmacology; Isoflavones - urine; phytoestrogen; Phytoestrogens - pharmacology; Soy Foods

Two glucuronides (4′-O-, and 7-O-) and a glucuronyl (7-O-) sulfate (4′-O-) of genistein, two glucuronides (4′-O-, and 7-O-) and a glucuronyl (7-O-) sulfate (4′-O-) of daidzein, 7-O-glucuronides of glycitein, dihydrodaidzein and O-desmethylangolensin were isolated from the urine of volunteer subjects...