Enhanced cellular uptake and cytotoxicity of vorinostat through encapsulation in TPGS-modified liposomes

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 199; p. 111523
• Main Authors: Farooq, Muhammad Asim, Xinyu, Huang, Jabeen, Amna, Ahsan, Anam, Seidu, Theodora Amanda, Kutoka, Perpetua Takunda, Wang, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2021
• Subjects: antineoplastic activity; breast neoplasms; Cancer therapy; cytotoxicity; drugs; encapsulation; flow cytometry; fluorescence microscopy; histone deacetylase; hydrophobicity; Liposomes; particle size; permeability; Solubility; T-cell lymphoma; toxicity testing; TPGS; transmission electron microscopy; Vorinostat; Liposomes; Cancer therapy; Vorinostat; Solubility; TPGS

[Display omitted] •TPGS modified liposomes were prepared using thin film hydration following the probe ultra-sonication method.•Surfaced-coated liposomal formulation enhanced the drug loading, encapsulation efficiency, solubility, and drug release profile.•TPGS coating on liposomes surface demonstra...