Role of Intermediate Progenitor Cells in Cerebral Cortex Development

• Published in: Developmental neuroscience Vol. 30; no. 1-3; pp. 24 - 32
• Main Authors: Pontious, Adria, Kowalczyk, Tom, Englund, Chris, Hevner, Robert F.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2008
• Subjects: Animals; Cell Differentiation - physiology; Cerebral Cortex - cytology; Cerebral Cortex - embryology; Cerebral Cortex - physiology; Gene Expression Regulation, Developmental - genetics; Humans; Mice; Mini Review; Nerve Growth Factors - genetics; Nervous System Malformations - genetics; Nervous System Malformations - metabolism; Nervous System Malformations - physiopathology; Neural Pathways - embryology; Neural Pathways - physiology; Neurons - cytology; Neurons - physiology; Signal Transduction - genetics; Stem Cells - cytology; Stem Cells - physiology; Radial glia; Eomes transcription factor; Short neural precursors; Tbr2 gene; Basal progenitor cells; Pax6 gene

Intermediate progenitor cells (IPCs) are a type of neurogenic transient amplifying cells in the developing cerebral cortex. IPCs divide symmetrically at basal (abventricular) positions in the neuroepithelium to produce pairs of new neurons or, in amplifying divisions, pairs of new IPCs. In contrast,...