Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis

• Published in: Stem cells and development Vol. 25; no. 14; p. 1073
• Main Authors: Pires, Ana O, Mendes-Pinheiro, Barbara, Teixeira, Fábio G, Anjo, Sandra I, Ribeiro-Samy, Silvina, Gomes, Eduardo D, Serra, Sofia C, Silva, Nuno A, Manadas, Bruno, Sousa, Nuno, Salgado, Antonio J
• Format: Journal Article
• Language: English
• Published: United States 15.07.2016
• Subjects: Adipose Tissue - cytology; Apoptosis - drug effects; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Cell Differentiation - drug effects; Culture Media, Conditioned - pharmacology; Cytoprotection - drug effects; Humans; Mass Spectrometry; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - secretion; Neurites - drug effects; Neurites - metabolism; Neurotoxins - toxicity; Oxidative Stress - drug effects; Proteome - secretion; Proteomics - methods; Umbilical Cord - blood supply; Umbilical Cord - cytology

The use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic strategy for CNS-related conditions. Research in the last decade strongly suggests that MSC-mediated benefits are closely related with their secretome. Studies published in recent years have shown that the secretom...