NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions

• Published in: American journal of physiology: endocrinology and metabolism Vol. 299; no. 5; pp. E794 - E801
• Main Authors: Tantiwong, Puntip, Shanmugasundaram, Karthigayan, Monroy, Adriana, Ghosh, Sangeeta, Li, Mengyao, DeFronzo, Ralph A., Cersosimo, Eugenio, Sriwijitkamol, Apiradee, Mohan, Sumathy, Musi, Nicolas
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2010
• Subjects: Adult; Blood Glucose - metabolism; Blotting, Western; Caspase 8 - biosynthesis; Caspase 8 - genetics; Chemokine CCL2 - biosynthesis; Chemokine CCL2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Exercise - physiology; Fatty Acids, Nonesterified - blood; Female; Humans; Insulin - blood; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Male; Middle Aged; Muscle, Skeletal - metabolism; NF-kappa B - metabolism; Obesity - metabolism; Oxygen Consumption; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - chemistry; RNA, Messenger - genetics; Signal Transduction

NF-κB is a transcription factor that controls the gene expression of several proinflammatory proteins. Cell culture and animal studies have implicated increased NF-κB activity in the pathogenesis of insulin resistance and muscle atrophy. However, it is unclear whether insulin-resistant human subject...