Developing filamentous fungal chassis for natural product production

[Display omitted] •The growing demand for bioactive NPs has driven interests in microbial chassis.•Filamentous fungi are promising chassis to produce bioactive natural products.•Emphasis is placed on strategies for developing a filamentous fungal chassis. The growing demand for green and sustainable...

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Published inBioresource technology Vol. 415; p. 131703
Main Authors Fan, Jie, Wei, Peng-Lin, Li, Yuanyuan, Zhang, Shengquan, Ren, Zedong, Li, Wei, Yin, Wen-Bing
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.2025
Subjects
Biosynthesis
Escherichia coli
Filamentous fungal chassis
fungi
Gene elements
genetic engineering
Genetic manipulation
Metabolic pathway
Natural products
Saccharomyces cerevisiae
secondary metabolites
synthetic biology
technology
5-FOA
G3P
IPP
HR
PKS-NRPS hybrid
FYAC
DOTB
rtTA
ssDNA
vir
CMK
AD
GUS
sTF
DOX
FDFT
CDP-ME
Lig4
CDP-MEP
sgRNA
Gene elements
DMAPP
DXP
GFPP
DXS
DSBR
DXR
HDAC
SES
DNA-PKcs
BLM
BE
Ura
UAS
MRN
Uri
P
MBE
R
NLS
MEcPP
CtIP
HMND
SM
BARD1
CRISPR
FPPS
PALB2
ACP
TC
SQLE
AspGD
bZIP
TF
CRISPRi
GGPPS
SDSA
CRISPRa
EDDB
PAM
ETP
CPR
GPP
DBD
HMBPP
TAS
BRCA2
MDD
Cp
GPPS
AACT
IDI
HMGS
HMGR
DSB
PAXX
EXO1
RNP
Ti
sfGFP
CYP
AA-CoA
NR-PKS
BGC
Genetic manipulation
DHMBA
GBCP
Filamentous fungal chassis
JGI
GRC
MEP
MVA
PKS
MVAP
nCas9
FC
SAM
GGPP
NP
RPA
MVK
CBE
FPP
Biosynthesis
Metabolic pathway
XLF
HDS
HDR
VPR
MVAPP
CSN
NRPS
OS
FAC
HMG-CoA
BIR
PMK
Natural products
EPD
NHEJ
dCas
Online AccessGet full text
ISSN0960-8524
1873-2976
1873-2976
DOI10.1016/j.biortech.2024.131703

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Abstract [Display omitted] •The growing demand for bioactive NPs has driven interests in microbial chassis.•Filamentous fungi are promising chassis to produce bioactive natural products.•Emphasis is placed on strategies for developing a filamentous fungal chassis. The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic engineering have reinforced filamentous fungi as promising chassis cells to produce bioactive natural products. Compared to the most used model organisms, Escherichia coli and Saccharomyces cerevisiae, most filamentous fungi are natural producers of secondary metabolites and possess an inherent pre-mRNA splicing system and abundant biosynthetic precursors. In this review, we summarize recent advances in the application of filamentous fungi as chassis cells. Emphasis is placed on strategies for developing a filamentous fungal chassis, including the establishment of mature genetic manipulation and efficient genetic tools, the catalogue of regulatory elements, and the optimization of endogenous metabolism. Furthermore, we provide an outlook on the advanced techniques for further engineering and application of filamentous fungal chassis.
AbstractList The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic engineering have reinforced filamentous fungi as promising chassis cells to produce bioactive natural products. Compared to the most used model organisms, Escherichia coli and Saccharomyces cerevisiae, most filamentous fungi are natural producers of secondary metabolites and possess an inherent pre-mRNA splicing system and abundant biosynthetic precursors. In this review, we summarize recent advances in the application of filamentous fungi as chassis cells. Emphasis is placed on strategies for developing a filamentous fungal chassis, including the establishment of mature genetic manipulation and efficient genetic tools, the catalogue of regulatory elements, and the optimization of endogenous metabolism. Furthermore, we provide an outlook on the advanced techniques for further engineering and application of filamentous fungal chassis.The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic engineering have reinforced filamentous fungi as promising chassis cells to produce bioactive natural products. Compared to the most used model organisms, Escherichia coli and Saccharomyces cerevisiae, most filamentous fungi are natural producers of secondary metabolites and possess an inherent pre-mRNA splicing system and abundant biosynthetic precursors. In this review, we summarize recent advances in the application of filamentous fungi as chassis cells. Emphasis is placed on strategies for developing a filamentous fungal chassis, including the establishment of mature genetic manipulation and efficient genetic tools, the catalogue of regulatory elements, and the optimization of endogenous metabolism. Furthermore, we provide an outlook on the advanced techniques for further engineering and application of filamentous fungal chassis.
The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic engineering have reinforced filamentous fungi as promising chassis cells to produce bioactive natural products. Compared to the most used model organisms, Escherichia coli and Saccharomyces cerevisiae, most filamentous fungi are natural producers of secondary metabolites (SMs) and possess an inherent pre-mRNA splicing system and abundant biosynthetic precursors. In this review, we summarize recent advances in the application of filamentous fungi as chassis cells. Emphasis is placed on strategies for developing a filamentous fungal chassis, including the establishment of mature genetic manipulation and efficient genetic tools, the catalogue of regulatory elements, and the optimization of endogenous metabolism. Furthermore, we provide an outlook on the advanced techniques for further engineering and application of filamentous fungal chassis.
[Display omitted] •The growing demand for bioactive NPs has driven interests in microbial chassis.•Filamentous fungi are promising chassis to produce bioactive natural products.•Emphasis is placed on strategies for developing a filamentous fungal chassis. The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic engineering have reinforced filamentous fungi as promising chassis cells to produce bioactive natural products. Compared to the most used model organisms, Escherichia coli and Saccharomyces cerevisiae, most filamentous fungi are natural producers of secondary metabolites and possess an inherent pre-mRNA splicing system and abundant biosynthetic precursors. In this review, we summarize recent advances in the application of filamentous fungi as chassis cells. Emphasis is placed on strategies for developing a filamentous fungal chassis, including the establishment of mature genetic manipulation and efficient genetic tools, the catalogue of regulatory elements, and the optimization of endogenous metabolism. Furthermore, we provide an outlook on the advanced techniques for further engineering and application of filamentous fungal chassis.
The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic engineering have reinforced filamentous fungi as promising chassis cells to produce bioactive natural products. Compared to the most used model organisms, Escherichia coli and Saccharomyces cerevisiae, most filamentous fungi are natural producers of secondary metabolites and possess an inherent pre-mRNA splicing system and abundant biosynthetic precursors. In this review, we summarize recent advances in the application of filamentous fungi as chassis cells. Emphasis is placed on strategies for developing a filamentous fungal chassis, including the establishment of mature genetic manipulation and efficient genetic tools, the catalogue of regulatory elements, and the optimization of endogenous metabolism. Furthermore, we provide an outlook on the advanced techniques for further engineering and application of filamentous fungal chassis.
ArticleNumber 131703
Author Fan, Jie
Wei, Peng-Lin
Li, Yuanyuan
Zhang, Shengquan
Li, Wei
Yin, Wen-Bing
Ren, Zedong
Author_xml – sequence: 1
  givenname: Jie
  surname: Fan
  fullname: Fan, Jie
  email: fanjie@im.ac.cn
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
– sequence: 2
  givenname: Peng-Lin
  surname: Wei
  fullname: Wei, Peng-Lin
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
– sequence: 3
  givenname: Yuanyuan
  surname: Li
  fullname: Li, Yuanyuan
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
– sequence: 4
  givenname: Shengquan
  surname: Zhang
  fullname: Zhang, Shengquan
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
– sequence: 5
  givenname: Zedong
  surname: Ren
  fullname: Ren, Zedong
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
– sequence: 6
  givenname: Wei
  surname: Li
  fullname: Li, Wei
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
– sequence: 7
  givenname: Wen-Bing
  orcidid: 0000-0002-9184-3198
  surname: Yin
  fullname: Yin, Wen-Bing
  email: yinwb@im.ac.cn
  organization: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China
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Keywords 5-FOA
G3P
IPP
HR
PKS-NRPS hybrid
FYAC
DOTB
rtTA
ssDNA
vir
CMK
AD
GUS
sTF
DOX
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GGPPS
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CRISPRa
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CPR
GPP
DBD
HMBPP
TAS
BRCA2
MDD
Cp
GPPS
AACT
IDI
HMGS
HMGR
DSB
PAXX
EXO1
RNP
Ti
sfGFP
CYP
AA-CoA
NR-PKS
BGC
Genetic manipulation
DHMBA
GBCP
Filamentous fungal chassis
JGI
GRC
MEP
MVA
PKS
MVAP
nCas9
FC
SAM
GGPP
NP
RPA
MVK
CBE
FPP
Biosynthesis
Metabolic pathway
XLF
HDS
HDR
VPR
MVAPP
CSN
NRPS
OS
FAC
HMG-CoA
BIR
PMK
Natural products
EPD
NHEJ
dCas
Language English
License Copyright © 2024 Elsevier Ltd. All rights reserved.
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PublicationDate 2025-01-01
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PublicationTitle Bioresource technology
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Publisher Elsevier Ltd
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Snippet [Display omitted] •The growing demand for bioactive NPs has driven interests in microbial chassis.•Filamentous fungi are promising chassis to produce bioactive...
The growing demand for green and sustainable production of high-value chemicals has driven the interest in microbial chassis. Recent advances in synthetic...
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SubjectTerms Biosynthesis
Escherichia coli
Filamentous fungal chassis
fungi
Gene elements
genetic engineering
Genetic manipulation
Metabolic pathway
Natural products
Saccharomyces cerevisiae
secondary metabolites
synthetic biology
technology
Title Developing filamentous fungal chassis for natural product production
URI https://dx.doi.org/10.1016/j.biortech.2024.131703
https://www.ncbi.nlm.nih.gov/pubmed/39477163
https://www.proquest.com/docview/3122638730
https://www.proquest.com/docview/3200296485
Volume 415
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