Current Status of Precision Medicine in Colorectal Cancer in Japan

• Published in: International journal of molecular sciences Vol. 26; no. 11; p. 5029
• Main Authors: Kojitani, Yoshiki, Takeda, Masayuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.05.2025; MDPI
• Subjects: Analysis; Antimitotic agents; Antineoplastic agents; Biomarkers; Biomarkers, Tumor - genetics; Cancer; Colorectal cancer; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - therapy; DNA methylation; Drug therapy; Epidermal growth factor; Genetic Testing; Humans; Immunotherapy; Insurance coverage; Japan; Molecular Targeted Therapy - methods; Mutation; Precision Medicine - methods; Precision Medicine - trends; Review; Japan; United States > US; precision medicine; molecular targeted therapy; colorectal cancer; human epidermal growth factor receptor 2; Japan

Colorectal cancer (CRC) remains a major health burden in Japan, with precision medicine playing an increasingly critical role in treatment optimization. Key biomarkers, including RAS, BRAF, microsatellite instability/mismatch repair, and human epidermal growth factor receptor 2, can be used as a gui...