Self-assembled IR dye/mitoxantrone loaded Porphysomes nanosystem for enhanced combinatorial chemo-photothermal cancer therapy

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 241; p. 113985
• Main Authors: Pebam, Monika, Khatun, Sajmina, Ali, Mohammad Sadik, Srivastava, Aditya, Rengan, Aravind Kumar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2024
• Subjects: absorbance; adjuvants; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; bioimaging; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Breast Neoplasms - therapy; camouflage; cancer therapy; caspase-3; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemo-Photothermal therapy; Drug Screening Assays, Antitumor; dyes; Female; fever; Humans; Hyperthermia; Infrared Rays; irradiation; Mice; mitochondria; Mitoxantrone - administration & dosage; Mitoxantrone - chemistry; Mitoxantrone - pharmacology; Nanoparticles - chemistry; nanotechnology; oxidative stress; Particle Size; Photochemotherapy; photosensitizing agents; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Photothermal Therapy; Porphyrins - chemistry; Porphyrins - pharmacology; Porphysomes; singlet oxygen; species; Surface Properties; transfection; Transient Transfection; Chemo-Photothermal therapy; Porphysomes; Transient Transfection; Hyperthermia; Apoptosis
• ISSN: 0927-7765; 1873-4367; 1873-4367
• DOI: 10.1016/j.colsurfb.2024.113985

Chemo-photothermal therapy (PTT) is an emerging non-invasive cancer treatment modality. Light-responsive porphysomes (DPP IR Mtx @Lipo NPs) nanosystems ablate breast cancer cells upon oxidative stress and hyperthermia. The unique self-assembled porphysomes were formed spherical shape in the size ran...