The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis

• Published in: The American journal of dermatopathology Vol. 31; no. 2; p. 177
• Main Authors: Lazova, Rossitza, Gould Rothberg, Bonnie E, Rimm, David, Scott, Glynis
• Format: Journal Article
• Language: English
• Published: United States 01.04.2009
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, CD - metabolism; Cytoskeleton - metabolism; Cytoskeleton - pathology; Disease Progression; Female; GPI-Linked Proteins; Humans; Immunohistochemistry; Male; Melanocytes - metabolism; Melanocytes - pathology; Melanoma - metabolism; Melanoma - secondary; Middle Aged; Protein Array Analysis; Receptors, Virus - metabolism; Semaphorins - metabolism; Skin Neoplasms - metabolism; Skin Neoplasms - pathology

The transformation of normal melanocytes, or melanocyte stem cells, to melanoma, is a complex process involving multiple mechanisms. Loss of tumor suppressor proteins, which function as brakes on cell growth, migration, or cell survival, was recognized early on as an important mechanism for initiati...