Biological response modifiers render tumor cells susceptible to autologous effector mechanisms by influencing adhesion receptors

• Published in: Leukemia & lymphoma Vol. 10; no. 1-2; p. 25
• Main Authors: Schirren, C A, Völpel, H, Hoffmann, J C, Henning, S W, Qiao, L, Autschbach, F, Dengler, T J, Döhner, H, Meuer, S C
• Format: Journal Article
• Language: English
• Published: United States 1993
• Subjects: Antigens, CD - analysis; CD11 Antigens; CD58 Antigens; Cell Adhesion Molecules - analysis; Cell Adhesion Molecules - physiology; Cell Line; Cell Line, Transformed; Cytokines - pharmacology; Cytotoxicity, Immunologic; Humans; Intercellular Adhesion Molecule-1; Leukemia, T-Cell - immunology; Membrane Glycoproteins - analysis

Adhesion molecules such as CD2 and its ligand CD58 (LFA-3), as well as CD11a/18 (LFA-1) and CD54 (ICAM-1) regulate not only cell to cell attachment but also participate in lymphocyte activation, recirculation, and effector function including cytolytic activity towards tumor cells. We have investigat...