Characterizations of reflex and nonreflex changes in spastic multiple sclerosis

• Published in: Journal of neuroscience methods Vol. 231; pp. 3 - 8
• Main Authors: Zhang, Li-Qun, Chen, Kai, Kang, Sang Hoon, Sliwa, James A., Cohen, Bruce A., Rymer, W.Z., Wang, Liang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.07.2014
• Subjects: Actigraphy - instrumentation; Adult; Elasticity; Female; Humans; Knee; Knee Joint - physiopathology; Male; Middle Aged; Models, Neurological; Multiple Sclerosis; Multiple Sclerosis - physiopathology; Muscle Spasticity - physiopathology; Muscle, Skeletal - physiopathology; Nonlinear Dynamics; Physical Stimulation; Reflex, Stretch - physiology; Spasticity; Stiffness; Stretch reflex; Torque; Viscosity; Viscosity; Multiple Sclerosis; Knee; Spasticity; Stretch reflex; Stiffness
• ISSN: 0165-0270; 1872-678X; 1872-678X
• DOI: 10.1016/j.jneumeth.2014.01.014

•Simultaneous characterization of reflex and nonreflex changes in multiple sclerosis.•Viscosity and tonic reflex gain were lower with MS.•Phasic reflex gain and stiffness were higher with MS. Spasticity, an increased resistance of a limb to movement, is associated with functional limitations and a major source of disability in neurological disorders, including multiple sclerosis (MS) and stroke. Despite the clinical significance of spasticity in brain and spinal cord injuries, it is often not clear whether the spasticity is due to reflex or non-reflex changes. Reflex and nonreflex properties of the human knee joint were studied in eight MS patients with spasticity and ten healthy subjects. A digitally controlled joint driving device was used to apply small-amplitude, and band-limited white-noise perturbations to the knee to manifest the reflex and nonreflex properties. The subjects were asked to maintain a steady level of background muscle torque during the perturbation. A nonlinear delay differential equation model was used to characterize the reflex and intrinsic properties of the knee in terms of phasic stretch reflex gain, tonic stretch reflex gain, joint elastic stiffness, and coefficient of viscosity. It was found that joint coefficient of viscosity and tonic stretch reflex gain of the spastic MS patients were significantly lower than those of normal controls. On the other hand, spastic MS patients showed higher phasic stretch reflex gains than normal controls and a trend of increased joint stiffness. Simultaneous characterizations of changes in tonic and phasic reflexes and nonreflex changes in joint elastic stiffness and viscosity in neurological disorders may help us gain insight into mechanisms underlying spasticity and develop impairment-specific treatment.