KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats

A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 mole...

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Bibliographic Details
Published inCell adhesion and communication Vol. 3; no. 5; p. 375
Main Authors Stephens, P, Romer, J T, Spitali, M, Shock, A, Ortlepp, S, Figdor, C G, Robinson, M K
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1995
Subjects
Animals
Antibodies, Monoclonal - chemistry
Antibodies, Monoclonal - immunology
Antibody Specificity
Blotting, Western
CD18 Antigens - chemistry
CD18 Antigens - genetics
CD18 Antigens - immunology
Cell Adhesion - immunology
Cell Line - physiology
Cysteine - analysis
Cysteine - genetics
Epitope Mapping
Gene Expression - genetics
Gene Expression - immunology
Humans
Mice
Mice, Inbred BALB C
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - immunology
Time Factors
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Summary:A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 molecule between amino acids 406 and 570 in a region containing cysteine-rich repeats.
ISSN:1061-5385
DOI:10.3109/15419069509081292