Chronic nicotine differentially alters cocaine-induced locomotor activity in adolescent vs. adult male and female rats

• Published in: Neuropharmacology Vol. 46; no. 3; pp. 349 - 362
• Main Authors: Collins, Stephanie L, Izenwasser, Sari
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2004
• Subjects: Adolescence; Age Factors; Animals; Cocaine; Cocaine - pharmacology; Dose-Response Relationship, Drug; Female; Gender; Locomotor activity; Male; Motor Activity - drug effects; Motor Activity - physiology; Nicotine; Nicotine - administration & dosage; Rats; Rats, Sprague-Dawley; Sensitization; Sex Characteristics; Stereotyped Behavior - drug effects; Stereotyped Behavior - physiology; Adolescence; Cocaine; Sensitization; Gender; Locomotor activity; Nicotine

Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. Thi...