Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents

• Published in: Journal of child neurology Vol. 22; no. 6; p. 693
• Main Authors: Glauser, Tracy A, Dlugos, Dennis J, Dodson, W Edwin, Grinspan, Augusto, Wang, Steven, Wu, Shu-Chen
• Format: Journal Article
• Language: English
• Published: United States 01.06.2007
• Subjects: Adolescent; Anticonvulsants - therapeutic use; Child; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Epilepsy - drug therapy; Epilepsy - physiopathology; Female; Fructose - analogs & derivatives; Fructose - therapeutic use; Humans; International Cooperation; Male; Retrospective Studies; Topiramate; Treatment Outcome

A double-blind, dose-controlled study evaluated topiramate as monotherapy in 470 patients with newly diagnosed (< or = 3 months) epilepsy or epilepsy relapse in the absence of therapy. In addition to having at least 2 lifetime-unprovoked seizures, patients had 1 or 2 partial-onset seizures or gen...