Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis - Chen, Yi-Ling; Gutowska-Owsiak, Danuta; Hardman, Clare S; Westmoreland, Melanie; MacKenzie, Teena; Cifuentes, Liliana; Waithe, Dominic; Lloyd-Lavery, Antonia; Marquette, Allison; Londei, Marco; Ogg, Graham (Science translational medicine, 2019)
Keywords: Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Cell Movement - drug effects; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - immunology; Dermatitis, Atopic - metabolism; Eczema - immunology; Eczema - metabolism; Extracellular Fluid; Humans; Inflammation - drug therapy; Inflammation - immunology; Inflammation - metabolism; Interleukin-12 - metabolism; Interleukin-33 - immunology; Interleukin-33 - metabolism; Neutrophils - drug effects; Neutrophils - metabolism; Receptors, Interleukin-8A - metabolism; Skin - drug effects; Skin - immunology; Skin - metabolism