Cognitive Impairment in Fibromyalgia: A Meta-Analysis of Case-Control Studies
Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared w...
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Published in | Psychosomatic medicine Vol. 80; no. 5; p. 432 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
01.06.2018
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Abstract | Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls.
We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017.
Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p = .013; g = 1.22, p < .001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p < .001; g = 0.75, p < .001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p < .001, 95% CI = 0.09-0.13; B = 0.02, p < .001, 95% CI = 0.01-0.02, respectively).
Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies. |
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AbstractList | Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological tests have been inconsistent. The aim of the study was to determine domain-specific cognitive impairment in patients with fibromyalgia compared with healthy controls.
We conducted a meta-analysis that systematically searched six databases (PubMed, Ovid MEDLINE, Embase, CINAHL, PsycINFO, and Web of Science) for articles published before September 2017.
Twenty-three case-control studies with a total of 2096 participants were included in the meta-analysis. Cognitive function was significantly lower (g = 0.87, 95% confidence interval [CI] = 0.60-1.15) in individuals with fibromyalgia than in healthy controls. Large effect sizes were found in learning/memory and attention/psychomotor speed (g = 0.94, p = .013; g = 1.22, p < .001, respectively); medium effect sizes were reported in executive function and working memory (g = 0.72, p < .001; g = 0.75, p < .001, respectively). Depression and anxiety scores were associated with the effect size of group differences in cognitive function (B = 0.11, p < .001, 95% CI = 0.09-0.13; B = 0.02, p < .001, 95% CI = 0.01-0.02, respectively).
Cognitive impairment across different cognitive domains was found in individuals with fibromyalgia compared with healthy controls. Mood states (depression and anxiety) may explain the heterogeneity across studies. |
Author | Tsai, Pei-Shan Fang, Su-Chen Huang, Chun-Jen Wu, Yu-Lin Ko, Ling-Hsin |
Author_xml | – sequence: 1 givenname: Yu-Lin surname: Wu fullname: Wu, Yu-Lin organization: From the School of Nursing (Wu, Fang), College of Nursing, Taipei Medical University; Department of Anesthesiology (Huang), Wan Fang Hospital, Taipei Medical University; Graduate Institute of Clinical Medicine (Huang), College of Medicine, Taipei Medical University; Tungs' Taichung Metroharbor Hospital (Ko), Taichung; and School of Nursing (Tsai), College of Nursing, Taipei Medical University, Taiwan – sequence: 2 givenname: Chun-Jen surname: Huang fullname: Huang, Chun-Jen – sequence: 3 givenname: Su-Chen surname: Fang fullname: Fang, Su-Chen – sequence: 4 givenname: Ling-Hsin surname: Ko fullname: Ko, Ling-Hsin – sequence: 5 givenname: Pei-Shan surname: Tsai fullname: Tsai, Pei-Shan |
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Snippet | Cognitive dysfunction has been reported in individuals with fibromyalgia. However, findings regarding cognitive function examined using neuropsychological... |
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SubjectTerms | Adult Anxiety Disorders - epidemiology Anxiety Disorders - physiopathology Case-Control Studies Cognitive Dysfunction - physiopathology Comorbidity Depressive Disorder - epidemiology Depressive Disorder - physiopathology Female Fibromyalgia - epidemiology Fibromyalgia - physiopathology Humans Male Middle Aged |
Title | Cognitive Impairment in Fibromyalgia: A Meta-Analysis of Case-Control Studies |
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