Myo‐inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism

• Published in: The Journal of physiology Vol. 601; no. 18; pp. 4151 - 4169
• Main Authors: Watkins, Oliver C., Pillai, Reshma Appukuttan, Selvam, Preben, Yong, Hannah E.J., Cracknell‐Hazra, Victoria K.B., Sharma, Neha, Cazenave‐Gassiot, Amaury, Bendt, Anne K., Godfrey, Keith M., Lewis, Rohan M., Wenk, Markus R., Chan, Shiao‐Yng
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2023; John Wiley and Sons Inc
• Subjects: Acids; Diabetes mellitus; Diabetes, Gestational; Explants; Female; Fetuses; Gestational diabetes; Glucose; Glucose - pharmacology; Humans; Inositol; Insulin; Leptin; Leptin - pharmacology; Lipid metabolism; Lipids; Liquid chromatography; Mass spectroscopy; Metabolism; Oleic acid; Oleic Acid - pharmacology; Palmitic acid; Palmitic Acid - pharmacology; Phosphatidylethanolamine; Phosphatidylethanolamines; Phospholipids; Placenta; Placenta, Pregnancy, and Perinatal Physiology; Pregnancy; Pregnancy complications; Sex; fetal sex; fatty acid; placental metabolism; stable isotope; beta-oxidation; gestational diabetes

Well-regulated placental palmitic acid (PA) and oleic acid (OA) metabolism is vital for optimal placental function and fetal development, but dysregulation occurs with gestational diabetes (GDM). We hypothesized that such dysregulation might arise from increased maternofetal glucose, leptin or insul...