C-type natriuretic peptide plasma levels and whole blood mRNA expression show different trends in adolescents with different degree of endothelial dysfunction

• Published in: Peptides (New York, N.Y. : 1980) Vol. 124; p. 170218
• Main Authors: Del Ry, Silvia, Cabiati, Manuela, Bianchi, Vanessa, Randazzo, Emioli, Peroni, Diego, Clerico, Aldo, Federico, Giovanni
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2020
• Subjects: Adipogenesis; Adolescent; adolescents; autocrine signaling; blood plasma; Body Mass Index; C-type natriuretic peptide; Case-Control Studies; childhood; Endothelial function; Endothelium, Vascular - physiopathology; Female; gene expression; Glycated Hemoglobin A - analysis; Humans; hyperemia; inflammation; Insulin Resistance; leukocytes; Male; messenger RNA; mRNA expression; Natriuretic Peptide, C-Type - blood; Natriuretic Peptide, C-Type - genetics; natriuretic peptides; obesity; Obesity - blood; Obesity - physiopathology; quantitative polymerase chain reaction; radioimmunoassays; Reactive hyperemia index; Receptors, Atrial Natriuretic Factor - genetics; RNA, Messenger - blood; transcription (genetics); Endothelial function; Reactive hyperemia index; C-type natriuretic peptide; Adipogenesis; mRNA expression

•C-type natriuretic peptide (CNP) is an endogenous adipogenesis regulator.•CNP plasma levels and mRNA were evaluated, for the first time, in whole blood.•Normal and obese adolescents were enrolled.•A different trend was observed for CNP plasma levels and its expression.•Interesting area for new ther...