Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends

• Published in: Pharmacology & therapeutics (Oxford) Vol. 239; p. 108276
• Main Authors: Song, Sheng-Lei, Li, Bo, Carvalho, Mariana R., Wang, Hui-Jin, Mao, De-Li, Wei, Ji-Tao, Chen, Wei, Weng, Zhi-Hui, Chen, Yang-Chao, Deng, Chu-Xia, Reis, Rui L., Oliveira, Joaquim M., He, Yu-Long, Yan, Le-Ping, Zhang, Chang-Hua
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2022
• Subjects: cancer-on-a-chip; Digestive system cancer; In vitro 3D models; Organoids; Tumor microenvironment; hHSC; TCR; BE; MDSC; OTSC; 2D; Organoids; CAFs; mCRC; In vitro 3D models; PDO; Digestive system cancer; GC; CC; GI; IFN-DCs; Tumor microenvironment; PDX; OOAC; HCC; TIME; TME; hPBMC; 3D; hiPSCs; PC; PDAC; HAN; CRC; TCR-T; cancer-on-a-chip; TILs; NK; ALI; DC

Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research. However, their ability to enable cancer precision medicine is limited. Cell culture models cannot retai...