The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery

• Published in: Science translational medicine Vol. 10; no. 441
• Main Authors: Stoppe, Christian, Averdunk, Luisa, Goetzenich, Andreas, Soppert, Josefin, Marlier, Arnaud, Kraemer, Sandra, Vieten, Jil, Coburn, Mark, Kowark, Ana, Kim, Bong-Song, Marx, Gernot, Rex, Steffen, Ochi, Akinobu, Leng, Lin, Moeckel, Gilbert, Linkermann, Andreas, El Bounkari, Omar, Zarbock, Alexander, Bernhagen, Jürgen, Djudjaj, Sonja, Bucala, Richard, Boor, Peter
• Format: Journal Article
• Language: English
• Published: United States 16.05.2018
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - epidemiology; Acute Kidney Injury - etiology; Acute Kidney Injury - urine; Animals; Antigens, Differentiation, B-Lymphocyte - chemistry; Antigens, Differentiation, B-Lymphocyte - metabolism; Antioxidants - metabolism; Cardiac Surgical Procedures - adverse effects; Cell Death; Histocompatibility Antigens Class II - chemistry; Histocompatibility Antigens Class II - metabolism; Humans; Incidence; Inflammation - pathology; Kidney - blood supply; Kidney - pathology; Lipid Peroxidation; Lipocalin-2 - urine; Macrophage Migration-Inhibitory Factors - blood; Macrophage Migration-Inhibitory Factors - deficiency; Macrophage Migration-Inhibitory Factors - urine; Mice, Inbred C57BL; Oxidative Stress; Protective Agents - metabolism; Protein Domains; Recombinant Proteins - administration & dosage; Recombinant Proteins - pharmacology; Reperfusion Injury - complications; Reperfusion Injury - pathology; Rhabdomyolysis - pathology

Acute kidney injury (AKI) represents the most frequent complication after cardiac surgery. Macrophage migration inhibitory factor (MIF) is a stress-regulating cytokine that was shown to protect the heart from myocardial ischemia-reperfusion injury, but its role in the pathogenesis of AKI remains unk...