Detailed analysis of metabolism reveals growth-rate-promoting interactions between Anaerostipes caccae and Bacteroides spp

• Published in: Anaerobe Vol. 79; p. 102680
• Main Authors: Kattel, Anna, Morell, Indrek, Aro, Valter, Lahtvee, Petri-Jaan, Vilu, Raivo, Jõers, Arvi, Nahku, Ranno
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2023
• Subjects: acetates; Bacteria; Bacteroides; Bacteroides thetaiotaomicron; Bacteroides vulgatus; carbon; Clostridiales; coculture; Flux balance analysis; galacturonic acid; Gut bacteria; heat production; Humans; inflammation; intestinal microorganisms; intestines; Isothermal microcalorimetry; lactic acid; Live therapeutics manufacturing; metabolism; Next-generation probiotics; probiotics; Serial batch; sorbitol; species; xylose; Live therapeutics manufacturing; B. thetaiotaomicron; Next-generation probiotics; FBA; Isothermal microcalorimetry; A. caccae; B. vulgatus; CDM; Flux balance analysis; NGP; Serial batch; Gut bacteria; IMC

Human gut microbiota species which are next-generation probiotics (NGPs) candidates are of high interest as they have shown the potential to treat intestinal inflammation and other diseases. Unfortunately, these species are often not robust enough for large-scale cultivation, especially in maintaini...