Subunit vaccine based on glycoprotein B protects pattern animal guinea pigs from tissue damage caused by infectious bovine rhinotracheitis virus

• Published in: Virus research Vol. 320; p. 198899
• Main Authors: Hou, Li-na, Wang, Feng-xue, Wang, Ya-xin, Guo, Hao, Liu, Chun-yu, Zhao, Hong-zhe, Yu, Ming-hua, Wen, Yong-jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2022
• Subjects: Animals; antibodies; Antibodies, Neutralizing; Antibodies, Viral; Bovine alphaherpesvirus 1; Bovine herpesvirus type 1; Cattle; cattle industry; genes; genetic vectors; Glycoprotein B; glycoproteins; Guinea Pigs; Herpesvirus 1, Bovine - genetics; histopathology; immunity; Infectious bovine rhinotracheitis; Infectious Bovine Rhinotracheitis - prevention & control; lungs; Prokaryotic expression; protective effect; secretion; Subunit vaccine; subunit vaccines; vaccination; Vaccines, Inactivated; Vaccines, Subunit - genetics; viral load; Viral Vaccines - genetics; viruses; Glycoprotein B; Infectious bovine rhinotracheitis; Prokaryotic expression; Subunit vaccine; Guinea pigs; Bovine herpesvirus type 1

•We obtained a BoHV-1 glycoprotein B subunit vaccine by prokaryotic expression.•BoHV-1 can successfully infect the guinea pigs model.•The immunological characteristics of gB subunit vaccine was investigated in guinea pigs model.•IBRV gB subunit vaccine protects pattern animal guinea pigs from tissue...