Balance of Th1/Th2 Cytokines Associated with the Preventive Effect of Incomplete Freund's Adjuvant on the Development of Adjuvant Arthritis in LEW Rats

• Published in: Journal of autoimmunity Vol. 17; no. 4; pp. 289 - 295
• Main Authors: Hossain, Aslam, Zheng, Cong Long, Kukita, Akiko, Kohashi, Osamu
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.12.2001; Elsevier
• Subjects: AA, cytokine, IFA, rats, Th1/Th2; Animals; Arthritis, Experimental - immunology; Arthritis, Experimental - prevention & control; Biological and medical sciences; Cytokines - biosynthesis; Cytokines - immunology; Diseases of the osteoarticular system; Experimental and animal immunopathology. Animal models; Female; Freund's Adjuvant - administration & dosage; Freund's Adjuvant - immunology; g-Interferon; Gene Expression Regulation - immunology; Immunopathology; Inflammatory joint diseases; Lipids; Male; Medical sciences; Rats; Rats, Inbred Lew; RNA, Messenger - biosynthesis; Th1 Cells - immunology; Th1 Cells - metabolism; Th2 Cells - immunology; Th2 Cells - metabolism; AA, cytokine, IFA, rats, Th1/Th2; Immunopathology; Animal model; Immune response; Rat; Pathogenesis; Rodentia; Diseases of the osteoarticular system; Cytokine; Th1 lymphocyte; Autoimmune disease; Inflammatory joint disease; Arthritis; Immune regulation; Cell subpopulation; Prevention; Vertebrata; Chronic; Mammalia; Incomplete Freund's adjuvant; Freund's adjuvant; Animal; Rheumatoid arthritis; Th2 lymphocyte; Lymphocyte

Complete Freund's adjuvant (CFA) could induce adjuvant arthritis (AA) in LEW rats and incomplete Freund's adjuvant (IFA) could induce oil induced arthritis (OIA) in DA but not in LEW rats. Lymph node cells (LNCs) from these AA and OIA rats showed increased mRNA expression of IFN-γ, IL-2 an...