Fenugreek seed mucilage grafted poly methacrylate pH-responsive hydrogel: A promising tool to enhance the oral bioavailability of methotrexate

• Published in: International journal of biological macromolecules Vol. 202; pp. 332 - 344
• Main Authors: Hussain, Hafiz Rashid, Bashir, Sajid, Mahmood, Asif, Sarfraz, Rai Muhammad, Kanwal, Misbah, Ahmad, Nadeem, Shah, Hamid Saeed, Nazir, Imran
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 31.03.2022
• Subjects: acrylamides; albino; Animals; BCS class IV drugs; bioavailability; Biological Availability; Drug Liberation; fenugreek; Fenugreek mucilage; free radicals; HeLa Cells; Humans; Hydrogels; Hydrogen-Ion Concentration; Methacrylates; Methotrexate; Methotrexate - pharmacology; mucilages; Oral bioavailability; pH-responsive hydrogel; pharmacokinetics; polymerization; Rabbits; Rats; Rats, Wistar; Seeds; thermal analysis; toxicity; Trigonella; Trigonella foenum-graecum; Fenugreek mucilage; pH-responsive hydrogel; Oral bioavailability; BCS class IV drugs; Methotrexate

This study aimed to develop the Fenugreek seed mucilage-based pH-responsive hydrogel system in order to improve the oral bioavailability of methotrexate (MTX). Fenugreek seed mucilage (FSM) was extracted from Trigonella foenum-graecum seeds. F1-F9 formulations of pH-responsive hydrogels were prepare...