Fenugreek seed mucilage grafted poly methacrylate pH-responsive hydrogel: A promising tool to enhance the oral bioavailability of methotrexate - Hussain, Hafiz Rashid; Bashir, Sajid; Mahmood, Asif; Sarfraz, Rai Muhammad; Kanwal, Misbah; Ahmad, Nadeem; Shah, Hamid Saeed; Nazir, Imran (International journal of biological macromolecules, 2022)
Keywords: acrylamides; albino; Animals; BCS class IV drugs; bioavailability; Biological Availability; Drug Liberation; fenugreek; Fenugreek mucilage; free radicals; HeLa Cells; Humans; Hydrogels; Hydrogen-Ion Concentration; Methacrylates; Methotrexate; Methotrexate - pharmacology; mucilages; Oral bioavailability; pH-responsive hydrogel; pharmacokinetics; polymerization; Rabbits; Rats; Rats, Wistar; Seeds; thermal analysis; toxicity; Trigonella; Trigonella foenum-graecum; Fenugreek mucilage; pH-responsive hydrogel; Oral bioavailability; BCS class IV drugs; Methotrexate