Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease

• Published in: Journal of Alzheimer's disease Vol. 32; no. 1; p. 169
• Main Authors: Fehlbaum-Beurdeley, Pascale, Sol, Olivier, Désiré, Laurent, Touchon, Jacques, Dantoine, Thierry, Vercelletto, Martine, Gabelle, Audrey, Jarrige, Anne-Charlotte, Haddad, Raphaël, Lemarié, Jean Christophe, Zhou, Weiyin, Hampel, Harald, Einstein, Richard, Vellas, Bruno
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2012
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Biomarkers; Cross-Sectional Studies; Data Interpretation, Statistical; Demography; Diagnostic and Statistical Manual of Mental Disorders; Disease Progression; Female; Humans; Inflammation - pathology; Male; Middle Aged; Neuropsychological Tests; Prospective Studies; Reproducibility of Results; RNA - chemistry; RNA - genetics; RNA - isolation & purification; Transcriptome - physiology

Biomarkers have gained an increased importance in the past years in helping physicians to diagnose Alzheimer's disease (AD). This study was designed to identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of the signature was...