Systematic identification and characterization of carboxylesterases in cynomolgus macaques

• Published in: Drug metabolism and disposition Vol. 42; no. 12; pp. 2002 - 2006
• Main Authors: Uno, Yasuhiro, Uehara, Shotaro, Hosokawa, Masakiyo, Imai, Teruko
• Format: Journal Article
• Language: English
• Published: United States 01.12.2014
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Carboxylic Ester Hydrolases - genetics; Carboxylic Ester Hydrolases - metabolism; DNA, Complementary - genetics; Genomics - methods; Humans; Kidney - metabolism; Liver - metabolism; Macaca fascicularis - genetics; Macaca fascicularis - metabolism; Phylogeny; Sequence Homology, Amino Acid

Carboxylesterase (CES) is important for detoxification of a wide range of drugs and xenobiotics and catalyzes cholesterol and fatty acid metabolism. Cynomolgus macaques are widely used in drug metabolism studies; however, cynomolgus CES has not been fully investigated at molecular levels, partly due...