Toxicant substitutes in immunological assays for mycotoxins detection: A mini review

•Toxicant-substitute based immunoassays for detecting mycotoxins were reviewed.•Toxicant substitute-based assays showed satisfying sensitivity and reliability.•Toxicant substitutes facilitate the standardization of immunoassays for mycotoxins.•Toxicant substitutes pose reduced harmfulness to operato...

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Published inFood chemistry Vol. 344; p. 128589
Main Authors Li, Ping, Deng, Shengliang, Zech Xu, Zhenjiang
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.05.2021
Subjects
Anti-idiotypic antibody
Antibodies, Anti-Idiotypic - immunology
Antibodies, Anti-Idiotypic - metabolism
Antigens - analysis
Antigens - immunology
Bacteriophages - metabolism
detection
environment
food chemistry
food safety
Humans
Immunoassay
Immunoassay - methods
Mimotope
Mycotoxin
mycotoxins
Mycotoxins - analysis
Nanobody
Single-Domain Antibodies - chemistry
Single-Domain Antibodies - immunology
standardization
Toxicant substitutes
Nanobody
Immunoassay
Anti-idiotypic antibody
Toxicant substitutes
Mimotope
Mycotoxin
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Abstract •Toxicant-substitute based immunoassays for detecting mycotoxins were reviewed.•Toxicant substitute-based assays showed satisfying sensitivity and reliability.•Toxicant substitutes facilitate the standardization of immunoassays for mycotoxins.•Toxicant substitutes pose reduced harmfulness to operators and environment.•Toxicant substitutes contribute to develop eco-friendly immunoassays. Recurring mycotoxins contamination has posedaseriousthreatto food safety worldwide. Competitive immunoassays are widely used techniques for high-throughput mycotoxins detection in agricultural products and foods. However, the inevitable introduction of mycotoxin conjugates produced by chemical conjugation usually results in complicated by-products, large batch errors and threats to operators and environment. Biologically derived surrogates of mycotoxin conjugates or mycotoxin standards are renewable immunoreagents. They can serve the same function as the responding counterparts in the immunoassays. The substitute-based immunoassays exhibit satisfactory sensitivity, pose less health threats to operators and environment, and contribute to the standardization of immunoassays for mycotoxins. This review focuses on the current applications of substitute-based immunoassays, clarifies their underlying mechanisms and provides a careful comparison. Challenges and future prospects are discussed.
AbstractList Recurring mycotoxins contamination has posedaseriousthreatto food safety worldwide. Competitive immunoassays are widely used techniques for high-throughput mycotoxins detection in agricultural products and foods. However, the inevitable introduction of mycotoxin conjugates produced by chemical conjugation usually results in complicated by-products, large batch errors and threats to operators and environment. Biologically derived surrogates of mycotoxin conjugates or mycotoxin standards are renewable immunoreagents. They can serve the same function as the responding counterparts in the immunoassays. The substitute-based immunoassays exhibit satisfactory sensitivity, pose less health threats to operators and environment, and contribute to the standardization of immunoassays for mycotoxins. This review focuses on the current applications of substitute-based immunoassays, clarifies their underlying mechanisms and provides a careful comparison. Challenges and future prospects are discussed.
Recurring mycotoxins contamination has posedaseriousthreatto food safety worldwide. Competitive immunoassays are widely used techniques for high-throughput mycotoxins detection in agricultural products and foods. However, the inevitable introduction of mycotoxin conjugates produced by chemical conjugation usually results in complicated by-products, large batch errors and threats to operators and environment. Biologically derived surrogates of mycotoxin conjugates or mycotoxin standards are renewable immunoreagents. They can serve the same function as the responding counterparts in the immunoassays. The substitute-based immunoassays exhibit satisfactory sensitivity, pose less health threats to operators and environment, and contribute to the standardization of immunoassays for mycotoxins. This review focuses on the current applications of substitute-based immunoassays, clarifies their underlying mechanisms and provides a careful comparison. Challenges and future prospects are discussed.Recurring mycotoxins contamination has posedaseriousthreatto food safety worldwide. Competitive immunoassays are widely used techniques for high-throughput mycotoxins detection in agricultural products and foods. However, the inevitable introduction of mycotoxin conjugates produced by chemical conjugation usually results in complicated by-products, large batch errors and threats to operators and environment. Biologically derived surrogates of mycotoxin conjugates or mycotoxin standards are renewable immunoreagents. They can serve the same function as the responding counterparts in the immunoassays. The substitute-based immunoassays exhibit satisfactory sensitivity, pose less health threats to operators and environment, and contribute to the standardization of immunoassays for mycotoxins. This review focuses on the current applications of substitute-based immunoassays, clarifies their underlying mechanisms and provides a careful comparison. Challenges and future prospects are discussed.
•Toxicant-substitute based immunoassays for detecting mycotoxins were reviewed.•Toxicant substitute-based assays showed satisfying sensitivity and reliability.•Toxicant substitutes facilitate the standardization of immunoassays for mycotoxins.•Toxicant substitutes pose reduced harmfulness to operators and environment.•Toxicant substitutes contribute to develop eco-friendly immunoassays. Recurring mycotoxins contamination has posedaseriousthreatto food safety worldwide. Competitive immunoassays are widely used techniques for high-throughput mycotoxins detection in agricultural products and foods. However, the inevitable introduction of mycotoxin conjugates produced by chemical conjugation usually results in complicated by-products, large batch errors and threats to operators and environment. Biologically derived surrogates of mycotoxin conjugates or mycotoxin standards are renewable immunoreagents. They can serve the same function as the responding counterparts in the immunoassays. The substitute-based immunoassays exhibit satisfactory sensitivity, pose less health threats to operators and environment, and contribute to the standardization of immunoassays for mycotoxins. This review focuses on the current applications of substitute-based immunoassays, clarifies their underlying mechanisms and provides a careful comparison. Challenges and future prospects are discussed.
ArticleNumber 128589
Author Deng, Shengliang
Li, Ping
Zech Xu, Zhenjiang
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  givenname: Zhenjiang
  surname: Zech Xu
  fullname: Zech Xu, Zhenjiang
  email: zhx054@ucsd.edu
  organization: State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China
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Keywords Nanobody
Immunoassay
Anti-idiotypic antibody
Toxicant substitutes
Mimotope
Mycotoxin
Language English
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Snippet •Toxicant-substitute based immunoassays for detecting mycotoxins were reviewed.•Toxicant substitute-based assays showed satisfying sensitivity and...
Recurring mycotoxins contamination has posedaseriousthreatto food safety worldwide. Competitive immunoassays are widely used techniques for high-throughput...
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SubjectTerms Anti-idiotypic antibody
Antibodies, Anti-Idiotypic - immunology
Antibodies, Anti-Idiotypic - metabolism
Antigens - analysis
Antigens - immunology
Bacteriophages - metabolism
detection
environment
food chemistry
food safety
Humans
Immunoassay
Immunoassay - methods
Mimotope
Mycotoxin
mycotoxins
Mycotoxins - analysis
Nanobody
Single-Domain Antibodies - chemistry
Single-Domain Antibodies - immunology
standardization
Toxicant substitutes
Title Toxicant substitutes in immunological assays for mycotoxins detection: A mini review
URI https://dx.doi.org/10.1016/j.foodchem.2020.128589
https://www.ncbi.nlm.nih.gov/pubmed/33246689
https://www.proquest.com/docview/2465442308
https://www.proquest.com/docview/2524327971
Volume 344
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