Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging

We propose a fluorescent x-ray computed tomography method using an array of detectors with an incident sheet beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution. In this study, we prove the feasibility of this concept and investigate its imaging properties, i...

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Published inOptics letters Vol. 33; no. 21; p. 2494
Main Authors Huo, Qingkai, Yuasa, Tetsuya, Akatsuka, Takao, Takeda, Tohoru, Wu, Jin, Thet-Thet-Lwin, Hyodo, Kazuyuki, Dilmanian, F Avraham
Format Journal Article
LanguageEnglish
Published United States 01.11.2008
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Summary:We propose a fluorescent x-ray computed tomography method using an array of detectors with an incident sheet beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution. In this study, we prove the feasibility of this concept and investigate its imaging properties, including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal mouse brain using a preliminary imaging system with monochromatic synchrotron x rays.
ISSN:0146-9592
DOI:10.1364/OL.33.002494