Effectiveness of human spermatozoa biomarkers as indicators of structural damage during cryopreservation

• Published in: Cryobiology Vol. 78; pp. 90 - 94
• Main Authors: Gómez-Torres, María José, Medrano, Llanos, Romero, Alejandro, Fernández-Colom, Pedro José, Aizpurúa, Jon
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2017
• Subjects: Acrosome; Acrosome - physiology; acrosome reaction; biomarkers; Biomarkers - analysis; Cell Survival - physiology; Cryodamage; Cryopreservation; Cryopreservation - methods; cryoprotectants; Cryoprotective Agents - pharmacology; Cytoskeleton; DNA; DNA - genetics; DNA fragmentation; DNA Fragmentation - drug effects; Fertility Preservation - methods; freeze-thaw cycles; Freezing; Humans; Male; male fertility; metabolism; Morphology; principal component analysis; semen; Semen - drug effects; Semen Analysis; Semen Preservation - methods; Sperm Count; Sperm Motility - physiology; Spermatozoa; Spermatozoa - drug effects; Spermatozoa - ultrastructure; thawing; Spermatozoa; Cryopreservation; Morphology; Cryodamage; DNA fragmentation; Cytoskeleton; Acrosome
• ISSN: 0011-2240; 1090-2392; 1090-2392
• DOI: 10.1016/j.cryobiol.2017.06.008

Human spermatozoa cryopreservation techniques are used to maintain and protect male fertility in cases such as infertility and malignancy treatments. However, during cryopreservation, the spermatozoa's metabolic rate is reduced and they undergo dramatic functional and structural changes owing t...