Oligonucleotide Microarray Analysis of Gene Expression in Follicle-Stimulating Hormone-Treated Rat Sertoli Cells

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 16; no. 12; pp. 2780 - 2792
• Main Authors: McLean, Derek J, Friel, Patrick J, Pouchnik, Derek, Griswold, Michael D
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.12.2002; Oxford University Press
• Subjects: Acyltransferases - genetics; Animals; Blotting, Northern; Bucladesine - pharmacology; Cells, Cultured; Diacylglycerol O-Acyltransferase; DNA-Binding Proteins - genetics; Follicle Stimulating Hormone - pharmacology; Gene Expression - drug effects; Immediate-Early Proteins - genetics; Male; Nuclear Receptor Subfamily 4, Group A, Member 1; Oligonucleotide Array Sequence Analysis; Protein Tyrosine Phosphatases - genetics; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger - analysis; Sertoli Cells - metabolism; Transcription Factors - genetics

Spermatogenesis requires the presence of functional somatic Sertoli cells in the seminiferous tubules of the testis. Sertoli cells provide support and factors necessary for the successful progression of germ cells into spermatozoa. Sertoli cells are regulated to a large degree by the glycoprotein ho...